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DNA helicase B Antibodies
AND HELB ELISA kits, DNA helicase B Proteins
Many biological assays use antibodies to detect DNA helicase B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DNA helicase B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DNA helicase B antibodies...
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HELB Overview
Facts about DNA helicase B.
DNA helicase B (HELB)
Recruitment to single-stranded DNA (ssDNA) following DNA damage contributes to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB (PubMed:26774285). As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation (PubMed:26774285).
Acts independently of TP53BP1 (PubMed:26774285). Unwinds duplex DNA with 5'-3' polarity.
Gene Information
| Human | |
|---|---|
| Gene Name: | HELB |
| Uniprot: | Q8NG08 |
| Entrez: | 92797 |
Family
| Belongs to: |
|---|
| RecD family |
Alternative Names
DNA helicase B; hDHB; helicase (DNA) B
Molecular Weight
Mass (kDA):
123.252 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q14.3|12q |
| Sequence: | 12; NC_000012.12 (66302493..66343643) |
Tissue Specificity
Highly expressed in testis and thymus and weakly in liver, spleen, kidney and brain.
Subcellular Localizations
Nucleus. Cytoplasm. Chromosome. Predominantly nuclear (PubMed:15146062). Phosphorylation at Ser-967 by CDK2 during the G1/S transition results in its nuclear export into the cytoplasm as cells approach and progress through S phase (PubMed:15146062). Following DNA damage, recruited to sites of double-strand breaks by the RPA complex (PubMed:26774285). Recruited to chromatin following DNA damage induced by UV irradiation, or camptothecin or hydroxyurea treatment (PubMed:22194613).
Diseases
- Osteosarcoma
- Extra Unidentified Structurally Abnormal Chromosome (disorder)
- Arthritis
- Edema
- Infectious Mononucleosis
- Chromosome Markers
- Retroperitoneal Neoplasms
- Liposarcoma
Pathways
- Dna Replication
- S Phase
- Single-stranded Dna Binding
- Cell Cycle
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HELB
bosterbio.com/bosterbio-gene-info-cards/HELB
References
PMID: 12181327 by Taneja P., et al. A dominant-negative mutant of human DNA helicase B blocks the onset of chromosomal DNA replication.
PMID: 15146062 by Gu J., et al. Cell cycle-dependent regulation of a human DNA helicase that localizes in DNA damage foci.