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- Table of Contents
HES1 Antibodies
AND HES1 ELISA kits, HES1 Proteins
Many biological assays use antibodies to detect HES1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HES1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HES1 antibodies...
Designing a Western blot for HES1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the HES1 Western Blot GuideHES1 Infographic by Boster Bio
All HES1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01459
100 μl
Cat # M01459
100 μl
HES1 Overview
Facts about Transcription factor HES-1.
Transcription factor HES-1 (HES1)
Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1.
Binds DNA on N-box themes: 5'-CACNAG-3' with high affinity and on E-box themes: 5'-CANNTG-3' with low affinity (By similarity). May play a part in a functional FA core complex response to DNA cross-link harm, needing the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.
Gene Information
| Human | |
|---|---|
| Gene Name: | HES1 |
| Uniprot: | Q14469 |
| Entrez: | 3280 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
BHLHB39; bHLHb39hairy homolog (Drosophila); Class B basic helix-loop-helix protein 39; FLJ20408; Hairy and enhancer of split 1; hairy and enhancer of split 1, (Drosophila); Hairy homolog; Hairy-like protein; HES1; HES-1; hHL; HL; HRY; HRYHHL; transcription factor HES-1
Molecular Weight
Mass (kDA):
29.541 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q29 |
| Sequence: | 3; NC_000003.12 (194136148..194138732) |
Subcellular Localizations
Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Idiopathic Hypereosinophilic Syndrome
- Leukemia
- Nervousness
- Carcinoma
- Cell Transformation, Neoplastic
- Pituitary Diseases
- Precursor T-cell Lymphoblastic Leukemia-lymphoma
- Acute Lymphocytic Leukemia
- Malignant Paraganglionic Neoplasm
- Lymphoma
- Malignant Neoplasm Of Breast
Interacting Proteins
- SIRT1
Pathways
- Notch Signaling Pathway
- Cell Differentiation
- Cell Proliferation
- Neurogenesis
- Cell Cycle
- Pathogenesis
- Cell Growth
- Regeneration
- Cell Development
- Segmentation
- Localization
- Angiogenesis
- Cell Fate Determination
PTMs
- Phosphorylation
- Cleavage
- Methylation
- Acetylation
- Ubiquitination
- Demethylation
- Biotinylation
- Oxidation
Research Areas
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HES1
bosterbio.com/bosterbio-gene-info-cards/HES1
References
PMID: 8020957 by Feder J.N., et al. Genomic cloning and chromosomal localization of HRY, the human homolog to the Drosophila segmentation gene, hairy.
PMID: 12535671 by Takata T., et al. Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression.
2 Publications of Boster HES1 Antibodies & ELISA Kits
- PubMed ID: 32866517, Shi J,Han G,Wang J,Han X,Zhao M,Duan X,Mi L,Li N,Yin X,Shi H,Li C,Xu J,Yin F.Mat...
- PubMed ID: 24512546, Qiu M, Bao W, Wang J, Yang T, He X, Liao Y, Wan X. Bmc Cancer. 2014 Feb 11;14:78...
*More publications can be found for each product on its corresponding product page