HES6 Antibodies

AND HES6 ELISA kits, HES6 Proteins

Many biological assays use antibodies to detect HES6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HES6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HES6 antibodies...

We validate the specificity of these antibodies to HES6 by testing them on tissues known to express HES6 positively and negatively. Browse below to find the HES6 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for HES6? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the HES6 Western Blot Guide

HES6 Infographic by Boster Bio

All HES6 Products

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Product

Figures

Specificity

Applications

Price

Anti-HES-6 (A6) Antibody

Immunohistochemistry (IHC) analyzes of HES-6 (A6) pAb in paraffin-embedded human colorectal carcinoma tissue at 1:50

Human, Mouse, Rat

IHC

$405
Cat # A08067
100ul

Anti-HES-6 Antibody

Western Blot analysis of various cells using HES-6 Polyclonal Antibody diluted at 1:1000 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit

Western blot analysis of lysates from HeLa cells, using HES6 Antibody

Immunohistochemical analysis of paraffin-embedded human tonsil

Human, Mouse

ELISA, IF, IHC, WB

$380
Cat # A08067-1
100ul

HES6 (NM_018645) Human Over-expression Lysate

HES6 Human Over-expression Lysates NM_001142853

Human

$628
Cat # LS055502
20 µg, 100 µg

HES6 (NM_018645) Human Recombinant Protein

Coomassie blue staining of purified HES6 protein

$1249
Cat # PROTQ96HZ4
20 µg

HES6 Overview

Facts about Transcription cofactor HES-6.

HES6 3D structure. Source: alphafold

Transcription cofactor HES-6 (HES6)

Does not bind DNA itself but suppresses both HES1- mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its existence.

Promotes cell differentiation (By similarity). .

Gene Information

Human
Gene Name:	HES6
Uniprot:	Q96HZ4
Entrez:	55502

Family

Belongs to:

No superfamily

Alternative Names

BHLHB41; bHLHb41Class B basic helix-loop-helix protein 41; bHLHc23; C-HAIRY1; hairy and enhancer of split 6 (Drosophila); Hairy and enhancer of split 6; HES-6; transcription cofactor HES-6

Molecular Weight

Mass (kDA):
24.129 kDA

Genomic Context


Human

Location:	2q37.3
Sequence:	2; NC_000002.12 (238238267..238240038, complement)

Subcellular Localizations

Nucleus.

Diseases

Malignant Neoplasms
Idiopathic Hypereosinophilic Syndrome
Neoplasms
Nervousness
Malignant Neoplasm Of Prostate
Cell Transformation, Neoplastic
Brain Neoplasms
Leukemia
Adenocarcinoma
Prostatic Neoplasms
Malignant Neoplasm Of Lung
Malignant Neoplasm Of Pancreas
Neoplasm Metastasis

Malignant Neoplasm Of Breast
Carcinoma
Mammary Neoplasms
Liver Neoplasms, Experimental
Tumor Angiogenesis
Ovarian Neoplasm
Malignant Paraganglionic Neoplasm

Pathways

Neurogenesis
Cell Cycle
Cell Differentiation
Cell Proliferation
Notch Signaling Pathway
Segmentation
Cell Fate Determination
Cell Motility
Gliogenesis
Astrocyte Differentiation
Somitogenesis
Localization
Cell Growth

Angiogenesis
Transport
Gene Silencing
Immune Response
Proteolysis
Mesoderm Formation
Cell Cycle Arrest

PTMs

Phosphorylation

Cleavage

Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HES6

References

PMID: 10851137 by Bae S.-K., et al. The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation.

PMID: 11044617 by Vasiliauskas D., et al. Expression of mouse HES-6, a new member of the Hairy/Enhancer of split family of bHLH transcription factors.