HEXB Antibodies

AND HEXB ELISA kits, HEXB Proteins

Many biological assays use antibodies to detect HEXB, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HEXB in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HEXB antibodies...

We validate the specificity of these antibodies to HEXB by testing them on tissues known to express HEXB positively and negatively. Browse below to find the HEXB antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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HEXB Infographic by Boster Bio

All HEXB Products

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Specificity

Applications

Price

Anti-HEXB Antibody Picoband®

7 Q&As

Western blot analysis of HEXB using anti-HEXB antibody (PB9211)

Human

IHC, WB

$370
Cat # PB9211
100 μg/vial

HEXB Colorimetric Cell-Based ELISA

Western blot analysis of extracts from Jurkat cells

Human

ELISA

$480
Cat # EKC1671
1 kit, containing one 96-well plate and all necessary reagents

Anti-Hexb (S516) Antibody

Western blot (WB) analysis of Hexb (S516) pAb at 1:500 dilution
Lane1:A549 whole cell lysate(40ug)
Lane2:MCF-7 whole cell lysate(40ug)
Lane3:U-87MG whole cell lysate(40ug)

Human

IHC, WB

$405
Cat # A02290S516
100ul

HEXB Overview

Facts about Beta-hexosaminidase subunit beta.

HEXB 3D structure. Source: alphafold

Beta-hexosaminidase subunit beta (HEXB)

Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. .

Gene Information

Human
Gene Name:	HEXB
Uniprot:	P07686
Entrez:	3074

Family

Belongs to:

glycosyl hydrolase 20 family

Alternative Names

beta-hexosaminidase subunit beta; Beta-N-acetylhexosaminidase subunit beta; Cervical cancer proto-oncogene 7 protein; EC 3.2.1.52; ENC-1AS; HCC-7; HEL-248; HEXB; hexosaminidase B (beta polypeptide); Hexosaminidase B; Hexosaminidase subunit B; N-acetyl-beta-glucosaminidase subunit beta

Molecular Weight

Mass (kDA):
63.111 kDA

Genomic Context


Human

Location:	5q13.3
Sequence:	5; NC_000005.10 (74640023..74721288)

Subcellular Localizations

Lysosome.

Diseases

Sandhoff Disease
Gangliosidoses
Gangliosidoses, Gm2
Tay-sachs Disease
Lysosomal Storage Diseases
Storage Disease
Nerve Degeneration
Neurodegenerative Disorders
Nervousness
Tay-sachs Disease, Ab Variant
Motor Neuron Disease
Ataxia

Malignant Neoplasms
Atrophy
Encephalitis
Infective Disorder
Gliosis
Hereditary Diseases
Sphingolipidoses

Interacting Proteins

HEXA

Pathways

Pathogenesis
Localization
Fertilization
Mrna Splicing
Cell Death
Secretion
Transport
Cell Migration
Mrna Processing
Intracellular Transport
Glycosylation
Angiogenesis
Programmed Cell Death

Aging
Proteolysis
Osteoblast Proliferation
Tropism
Spermatogenesis
Inflammatory Response
Glycolipid Transport

PTMs

Glycosylation
Phosphorylation

Cleavage
Methylation

Deglycosylation

Research Areas

Neurodegeneration

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HEXB

References

PMID: 3013851 by Korneluk R.G., et al. Isolation of cDNA clones coding for the alpha-subunit of human beta- hexosaminidase. Extensive homology between the alpha- and beta- subunits and studies on Tay-Sachs disease.

PMID: 2977375 by Neote K., et al. Characterization of the human HEXB gene encoding lysosomal beta- hexosaminidase.