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HLA-DOA Antibodies
AND HLA-DOA ELISA kits, HLA-DOA Proteins
Many biological assays use antibodies to detect HLA-DOA, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HLA-DOA in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HLA-DOA antibodies...
Designing an IHC experiment for HLA-DOA? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the HLA-DOA IHC GuideHLA-DOA Infographic by Boster Bio
All HLA-DOA Products
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HLA-DOA Overview
Facts about HLA class II histocompatibility antigen, DO alpha chain.
HLA class II histocompatibility antigen, DO alpha chain (HLA-DOA)
Important modulator from the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.
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Gene Information
| Human | |
|---|---|
| Gene Name: | HLA-DOA |
| Uniprot: | P06340 |
| Entrez: | 3111 |
Family
| Belongs to: |
|---|
| MHC class II family |
Alternative Names
HLA class II histocompatibility antigen, DO alpha chain; HLA-D0-alpha; HLA-DNAHLADZ; HLA-DZA; lymphocyte antigen; major histocompatibility complex, class II, DN alpha; major histocompatibility complex, class II, DO alpha; MHC class II antigen DOA; MHC DN-alpha; MHC DZ alpha
Molecular Weight
Mass (kDA):
27.599 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6p21.32 |
| Sequence: | 6; NC_000006.12 (33004182..33009591, complement) |
Subcellular Localizations
Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER.
Diseases
- Malignant Neoplasms
- Rheumatoid Arthritis
- Chronic Lymphocytic Leukemia
- Dysequilibrium Syndrome
- Arthritis
- Leukemia
- Lymphoid Leukemia
- Acquired Immunodeficiency Syndrome
- Simian Acquired Immunodeficiency Syndrome
- Carcinoma
- Carcinogenesis
- Pyotraumatic Dermatitis
- Lupus Erythematosus, Systemic
Interacting Proteins
- REL
Pathways
- Methylation
- Reverse Transcription
- Gene Silencing
- Dna Methylation
- Oxidative Phosphorylation
- Pathogenesis
PTMs
- Methylation
Research Areas
- Asthma
- Diabetes Research
- Immunology
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HLA-DOA
bosterbio.com/bosterbio-gene-info-cards/HLA-DOA
References
PMID: 3000765 by Trowsdale J., et al. The human HLA class II alpha chain gene DZ alpha is distinct from genes in the DP, DQ and DR subregions.
PMID: 2499532 by Jonsson A.-K., et al. Human class II DNA and DOB genes display low sequence variability.