HLA-E Antibodies

AND HLA-E ELISA kits, HLA-E Proteins

Many biological assays use antibodies to detect HLA-E, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HLA-E in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HLA-E antibodies...

We validate the specificity of these antibodies to HLA-E by testing them on tissues known to express HLA-E positively and negatively. Browse below to find the HLA-E antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: CBLIF Next: HLA-F

HLA-E Infographic by Boster Bio

All HLA-E Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-HLA-E Purified Monoclonal Antibody

Anti-Hu HLA-E purified antibody (clone MEM-E/02) specificity verification by flow cytometry

Anti-Hu HLA-E purified antibody (concentration in sample 5 µg/ml, red-filled histogram) binds specifically to surface HLA-E on surface of HLA-E transfected LCL 721

Human, Primate

IHC-P, WB

$323
Cat # M01944
0.1 mg

HLAE (HLA-E) (NM_005516) Human Over-expression Lysate

Human

$628
Cat # LS003133
20 µg, 100 µg

HLA-E Overview

Facts about HLA class I histocompatibility antigen, alpha chain E.

HLA-E 3D structure. Source: alphafold

HLA class I histocompatibility antigen, alpha chain E (HLA-E)

Non-classical significant histocompatibility class Ib molecule involved in immune self-nonself discrimination. In complex with B2M/beta-2-microglobulin binds nonamer self-peptides derived from the signal sequence of classical MHC class Ia molecules (VL9 peptides) (PubMed:9754572, PubMed:18083576, PubMed:18339401).

Peptide-bound HLA-E-B2M heterotrimeric complex primarily functions as a ligand for natural killer (NK) cell inhibitory receptor KLRD1-KLRC1, allowing NK cells to monitor the expression of other MHC class I molecules in healthy cells and to tolerate self (PubMed:9754572, PubMed:9486650, PubMed:17179229, PubMed:18083576). Upon cellular stress, preferentially binds signal sequence-derived peptides from stress-induced chaperones and is no longer recognized by NK cell inhibitory receptor KLRD1- KLRC1, leading to diminished protection from NK cells (PubMed:12461076).

Gene Information

Human
Gene Name:	HLA-E
Uniprot:	P13747
Entrez:	3133

Family

Belongs to:

MHC class I family

Alternative Names

Clone OX18; DKFZp686P19218; EA1.2; EA2.1; HLA class I histocompatibility antigen, alpha chain E; HLA class I histocompatibility antigen, E alpha chain; HLA-6.2; HLAE; lymphocyte antigen; major histocompatibility complex, class I, E; MHC class I antigen E; MHC Class I RT1-A; MHC HLA-E alpha-1; MHC HLA-E alpha-2.1; MHC; OX18; QA1; RT1-A (OX18); RT1-A

Molecular Weight

Mass (kDA):
40.058 kDA

Genomic Context


Human

Location:	6p22.1
Sequence:	6; NC_000006.12 (30489508..30494194)

Tissue Specificity

Expressed in extravillous trophoblast cells and secretory endometrial cells during pregnancy (at protein level). The expression in nonlymphoid tissues is restricted to endothelial cells from all types of vessels, including arteries, veins, capillaries, and lymphatics (at protein level). In lymphoid organs, it is mainly expressed in endothelial venules, B and T cells, monocytes, macrophages, NK cells and megakaryocytes (at protein level).

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane.; [Soluble HLA class I histocompatibility antigen, alpha chain E]: Secreted.