Serpin-like protein HMSD Antibodies

This allelic splice variant of HMSD is the precursor of the histocompatibility antigen ACC-6. More commonly, minor histocompatibility antigens (mHags) refer to immunogenic peptide that, when complexed with MHC, can create an immune response after recognition by particular T-cells.

The peptides are derived from polymorphic intracellular proteins, which are cleaved by ordinary pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can excite T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor.