Heparanase (HPSE)

Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and center proteoglycans. Can also cleave the linkage between a glucuronic acid component and an N-sulfo glucosamine unit carrying out a 2-O-sulfo group, but not linkages between a glucuronic acid component and a 2-O-sulfated iduronic acid moiety.

It's basically inactive at neutral pH but becomes active under acidic conditions like during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation.