Histamine H2 receptor (HRH2)

The H2 subclass of histamine receptors mediates gastric acid secretion. Also seems to modulate gastrointestinal motility and intestinal secretion.

Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity).