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6 Q&As
Facts about 10 kDa heat shock protein, mitochondrial.
The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which serve as a back-to-back double ring. At a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with two heptameric rings of the co-chaperonin Hsp10.
Human | |
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Gene Name: | HSPE1 |
Uniprot: | P61604 |
Entrez: | 3336 |
Belongs to: |
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GroES chaperonin family |
10 kDa chaperonin; 10 kDa heat shock protein, mitochondrial; Chaperonin 10 Homolog; Chaperonin 10; CPN10HSP10; Early-pregnancy factor; EPF; GroES; heat shock 10kD protein 1 (chaperonin 10); heat shock 10kDa protein 1 (chaperonin 10); HSP10; HSPE1
Mass (kDA):
10.932 kDA
Human | |
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Location: | 2q33.1 |
Sequence: | 2; NC_000002.12 (197500379..197503449) |
Mitochondrion matrix.
This article will help you if you recently bought HSPE1 Antibody, HSPE1 Ferrmentas, or both. Here's a quick overview of these products. We'll also be discussing the benefits of each. Boster Bio: Best Uses Of The HSPE1Marker
The HSPE1 marker is a protein that is expressed in cells. It is vital for the production of mitochondrial ATP and acts as an antipoptotic mediator in PDAC. It also contributes to OXPHOS function maintenance and promotes ATP production. HSP60 is therefore a target for many cancer treatments. Metformin, for example, targets the production of ATP in mitochondria.
HSPE1 is an extremely conserved family of proteins involved in the immune system and stress response. They act as molecular chaperones, preventing protein aggregation by directing misfolded proteins along specific degradative pathways. HSP10, also called chaperonin 10 in intracellular multimer form, is a seven-subunit intracellular multimer that helps to fold non-native and native proteins.
The boster Bio HSPE1Antibody is a monoclonal anti-body that reacts with Human HSPE1. Its uses are as follows:
High affinity boster antibodies are recommended for the use in IHC, WB, or Flow assays. These antibodies were validated by testing them against 250 tissue samples. They have been quantitatively tested on recombinant and untransfected cell line. This ensures high levels of affinity and robustness. Boster Bio's HSPE1 Antibody can be relied upon to fulfill your research requirements.
Picoband HSPE1 Marker Picoband is capable of detecting expression of the protein HSP1. This gene is encoded within the cytoplasm by HSPh2 gene. The HSPh2 gene was highly conserved during evolution. The HSPh2 gene map is located on chromosome 13. After being exposed to heat, this protein is increased in HeLa cells. The HSPh2 gene map is located on chromosome 13. HSP105 expression could be an indicator of colorectal cancer.
Boster Bio HSPE1 Marker ferments a truncated form of the human HSPE1 gene. It has been cited extensively in the research community for over 25 years, and has been validated by Western Blotting, Immunohistochemistry, and ELISA. These fermentations are able to produce antibodies with high affinity towards human HSPE1.
PMID: 7914093 by Monzini N., et al. Identification and cloning of human chaperonin 10 homologue.
PMID: 7916212 by Chen J.J., et al. Isolation, sequence analysis and characterization of a cDNA encoding human chaperonin 10.