Oxidoreductase HTATIP2 (HTATIP2)

Oxidoreductase required for tumor suppression. NAPDH- bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors.

May act as a redox sensor connected to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic in addition to antiangiogenic properties.