IARS1 Antibodies

AND IARS1 ELISA kits, IARS1 Proteins

Many biological assays use antibodies to detect IARS1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IARS1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IARS1 antibodies...

We validate the specificity of these antibodies to IARS1 by testing them on tissues known to express IARS1 positively and negatively. Browse below to find the IARS1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for IARS1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the IARS1 IHC Guide

IARS1 Infographic by Boster Bio

All IARS1 Products

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Product

Figures

Specificity

Applications

Price

Anti-IARS1 Antibody Picoband®

Western blot analysis of IARS1 using anti-IARS1 antibody (A06805-1)

IHC analysis of IARS1 using anti-IARS1 antibody (A06805-1)

Human

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A06805-1
100 µg/vial

Isoleucyl tRNA synthetase (IARS) (NM_013417) Human Over-expression Lysate

Isoleucyl tRNA synthetase (IARS) Human Over-expression Lysates NM_002161

Human

$960
Cat # LS003376
20 µg, 100 µg

IARS1 Overview

Facts about Isoleucine--tRNA ligase, cytoplasmic.

IARS1 3D structure. Source: alphafold

Isoleucine--tRNA ligase, cytoplasmic (IARS1)

Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. .

Gene Information

Human
Gene Name:	IARS1
Uniprot:	P41252
Entrez:	3376

Family

Belongs to:

class-I aminoacyl-tRNA synthetase family

Alternative Names

Isoleucine--tRNA ligase, cytoplasmic

Molecular Weight

Mass (kDA):
144.498 kDA

Genomic Context


Human

Location:	9q22.31
Sequence:	9; NC_000009.12 (92210207..92293697, complement)

Tissue Specificity

Expressed in liver and muscle (at protein level).

Subcellular Localizations

Cytoplasm. Cytoplasm, cytosol.

Diseases

Growth retardation, impaired intellectual development, hypotonia, and hepatopathy (GRIDHH)

Interacting Proteins

EPRS

PTMs

Acetylation

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IARS1

References

PMID: 8052601 by Shiba K., et al. Human cytoplasmic isoleucyl-tRNA synthetase: selective divergence of the anticodon-binding domain and acquisition of a new structural unit.

PMID: 7721108 by Nichols R.C., et al. Human isoleucyl-tRNA synthetase: sequence of the cDNA, alternative mRNA splicing, and the characteristics of an unusually long C-terminal extension.