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Islet cell autoantigen 1 Antibodies
AND ICA1 ELISA kits, Islet cell autoantigen 1 Proteins
Many biological assays use antibodies to detect Islet cell autoantigen 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Islet cell autoantigen 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Islet cell autoantigen 1 antibodies...
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ICA1 Infographic by Boster Bio
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ICA1 Overview
Facts about Islet cell autoantigen 1.
Islet cell autoantigen 1 (ICA1)
May play a role in neurotransmitter secretion. .
.
Gene Information
| Human | |
|---|---|
| Gene Name: | ICA1 |
| Uniprot: | Q05084 |
| Entrez: | 3382 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
diabetes mellitus type I autoantigen; ICA1; ICA69; ICAp69; ICAp69Islet cell autoantigen p69,69 kDa islet cell autoantigen; islet cell autoantigen 1 (69kD); islet cell autoantigen 1 isoform; islet cell autoantigen 1; islet cell autoantigen 1, 69kDa; p69
Molecular Weight
Mass (kDA):
54.645 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7p21.3 |
| Sequence: | 7; NC_000007.14 (8113184..8262687, complement) |
Subcellular Localizations
Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. Predominantly cytosolic. Also exists as a membrane-bound form which has been found associated with synaptic vesicles and also with the Golgi complex and immature secretory granules.
Diseases
- Diabetes Mellitus, Insulin-dependent
- Diabetes Mellitus
- Autoimmunity
- Autoimmune Reaction
- Autoimmune Diseases
- Insulinoma
- Lupus Erythematosus, Systemic
- Rheumatoid Arthritis
- Arthritis
- Diabetes Mellitus, Experimental
- Prediabetes Syndrome
- Primary Sj??gren's Syndrome
Interacting Proteins
- CCDC28A
- ING5
- MBD3
- RAB2A
- RAB2B
Pathways
- Pathogenesis
- Cell Proliferation
- Immune Response
- Localization
- Translation
- T Cell Proliferation
- Secretion
- Transport
- Cell Activation
- Insulin Secretion
- Photosynthesis
- T Cell Activation
- Neurotransmitter Secretion
PTMs
Research Areas
- Diabetes Research
- Growth and Development
- Neuronal Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ICA1
bosterbio.com/bosterbio-gene-info-cards/ICA1
References
PMID: 8326004 by Pietropaolo M., et al. Islet cell autoantigen 69 kD (ICA69). Molecular cloning and characterization of a novel diabetes-associated autoantigen.
PMID: 7918678 by Miyazaki I., et al. Cloning of human and rat p69 cDNA, a candidate autoimmune target in type 1 diabetes.