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- Table of Contents
ID4 Antibodies
AND ID4 ELISA kits, ID4 Proteins
Many biological assays use antibodies to detect ID4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ID4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ID4 antibodies...
Designing a Western blot for ID4? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ID4 Western Blot GuideID4 Infographic by Boster Bio
All ID4 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA
$480
Cat # EKC1725
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1725
1 kit, containing one 96-well plate and all necessary reagents
ID4 Overview
Facts about DNA-binding protein inhibitor ID-4.
DNA-binding protein inhibitor ID-4 (ID4)
Transcriptional regulator (lacking a basic DNA binding domain) which simplifies the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, such as cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation (By similarity).
. .
Gene Information
| Human | |
|---|---|
| Gene Name: | ID4 |
| Uniprot: | P47928 |
| Entrez: | 3400 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
bHLHb27BHLHB27; Class B basic helix-loop-helix protein 27; DNA-binding protein inhibitor ID-4; IDB4; Inhibitor of DNA binding 4; inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
Molecular Weight
Mass (kDA):
16.622 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6p22.3 |
| Sequence: | 6; NC_000006.12 (19837370..19842197) |
Subcellular Localizations
Nucleus.
Diseases
- Neoplasms
- Malignant Neoplasms
- Lymphohistiocytosis, Hemophagocytic
- Cell Transformation, Neoplastic
- Leukemia
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Malignant Paraganglionic Neoplasm
- Nervousness
- Neoplasm Metastasis
- Leukemia, Myelocytic, Acute
- Carcinogenesis
- Myeloid Leukemia
Interacting Proteins
- NCK1
Pathways
- Methylation
- Cell Proliferation
- Cell Cycle
- Cell Differentiation
- Dna Methylation
- Gene Silencing
- Cell Growth
- Pathogenesis
- Localization
- Neurogenesis
- Oligodendrocyte Differentiation
- Spermatogenesis
- Angiogenesis
PTMs
- Methylation
- Demethylation
- Phosphorylation
- Reduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ID4
bosterbio.com/bosterbio-gene-info-cards/ID4
References
PMID: 9872455 by Rigolet M., et al. cDNA cloning, tissue distribution and chromosomal localization of the human ID4 gene.
PMID: 7665172 by Pagliuca A., et al. Molecular cloning of ID4, a novel dominant negative helix-loop-helix human gene on chromosome 6p21.3-p22.