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IDH3B Antibodies
AND IDH3B ELISA kits, IDH3B Proteins
Many biological assays use antibodies to detect IDH3B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IDH3B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IDH3B antibodies...
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IDH3B Infographic by Boster Bio
All IDH3B Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IP, IHC, WB
$370
Cat # A09433-3
100 μg/vial
Cat # A09433-3
100 μg/vial
IDH3B Overview
Facts about Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial.
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (IDH3B)
Plays a structural role to facilitate the assembly and make sure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the complete activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the meeting and combined function of both heterodimers.
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Gene Information
| Human | |
|---|---|
| Gene Name: | IDH3B |
| Uniprot: | O43837 |
| Entrez: | 3420 |
Family
| Belongs to: |
|---|
| isocitrate and isopropylmalate dehydrogenases family |
Alternative Names
EC 1.1.1; EC 1.1.1.41; FLJ11043; H-IDHB; isocitrate dehydrogenase [NAD] subunit beta, mitochondrial; isocitrate dehydrogenase 3 (NAD+) beta; isocitrate dehydrogenase, NAD(+)-specific, mitochondrial, beta subunit; Isocitric dehydrogenase subunit beta; MGC903; NAD(+)-specific ICDH subunit beta; NAD+-specific ICDH; NAD+-specific isocitrate dehydrogenase b subunit; NAD+-specific isocitrate dehydrogenase beta; RP46
Molecular Weight
Mass (kDA):
42.184 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 20p13 |
| Sequence: | 20; NC_000020.11 (2658394..2664223, complement) |
Subcellular Localizations
Mitochondrion.
Diseases
- Retinitis Pigmentosa
- Carcinoma
- Neoplasms
- Neoplasm Metastasis
- Retinal Degeneration
- Liver Carcinoma
- Hepatitis
- Nerve Degeneration
- Malignant Neoplasm Of Liver
- Lung Diseases
- Malignant Neoplasm Of Lung
Pathways
- Translation
- Metabolic Process
- Cell Cycle
- Hydrogen Peroxide Metabolic Process
- Protein Folding
- Cellular Response To Reactive Oxygen Species
- Response To Reactive Oxygen Species
- Aging
- Immune Response
PTMs
- Oxidation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IDH3B
bosterbio.com/bosterbio-gene-info-cards/IDH3B
References
PMID: 10601238 by Kim Y.-O., et al. Identification and functional characterization of a novel, tissue- specific NAD+-dependent isocitrate dehydrogenase beta subunit isoform.
PMID: 28098230 by Ma T., et al. Molecular mechanism of the allosteric regulation of the alphagamma heterodimer of human NAD-dependent isocitrate dehydrogenase.