IER2 Antibodies

AND IER2 ELISA kits, IER2 Proteins

Many biological assays use antibodies to detect IER2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IER2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IER2 antibodies...

We validate the specificity of these antibodies to IER2 by testing them on tissues known to express IER2 positively and negatively. Browse below to find the IER2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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IER2 Infographic by Boster Bio

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IER2 (NM_004907) Human Over-expression Lysate

Human

$628
Cat # LS009592
20 µg, 100 µg

IER2 Overview

Facts about Immediate early response gene 2 protein.

IER2 3D structure. Source: alphafold

Immediate early response gene 2 protein (IER2)

DNA-binding protein that seems to act as a transcription factor (PubMed:19584537). Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells (By similarity).

May mediate with FIBP FGF-signaling at the institution of laterality in the embryo (By similarity). Promotes cell motility, seems to stimulate tumor metastasis (PubMed:22120713).

Gene Information

Human
Gene Name:	IER2
Uniprot:	Q9BTL4
Entrez:	9592

Family

Belongs to:

IER family

Alternative Names

ETR101MGC111472; immediate early response 2; immediate early response gene 2 protein; MGC15265; Protein ETR101

Molecular Weight

Mass (kDA):
24.196 kDA

Genomic Context


Human

Location:	19p13.13
Sequence:	19; NC_000019.10 (13150411..13154911)

Tissue Specificity

Expressed in activated T-cells (at protein level) (PubMed:22120713). Expression increases in metastatic tumor cells (at protein level) (PubMed:22120713).

Subcellular Localizations

Cytoplasm. Nucleus. Cytoplasmic during quiescence, translocates to the nucleus upon stimulation.

Diseases

Malignant Neoplasms
Pseudorabies
Neoplasms
Infective Disorder
Autoimmunity
Neoplasm Metastasis
Brain Ischemia
Tumor Progression
Occlusion, Middle Cerebral Artery
Neoplasm Invasiveness
Infectious Bovine Rhinotracheitis
Meningoencephalitis

Hemorrhage
Pancreatic Neoplasm
Acute Promyelocytic Leukemia
Infarction, Middle Cerebral Artery
Lupus Erythematosus, Systemic
Pheochromocytoma

Pathways

Cell Death
Localization
Membrane Depolarization
Gastrulation
Cell Proliferation
Convergent Extension
Cell Motility
Mrna Stabilization

Cellular Process
Pathogenesis
Contact Inhibition

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IER2

References

PMID: 2061303 by Shimizu N., et al. Expression of a novel immediate early gene during 12-O- tetradecanoylphorbol-13-acetate-induced macrophagic differentiation of HL-60 cells.

PMID: 19584537 by Takaya T., et al. Functional analyses of immediate early gene ETR101 expressed in yeast.