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- Table of Contents
IKBKG Antibodies
AND IKBKG ELISA kits, IKBKG Proteins
Many biological assays use antibodies to detect IKBKG, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IKBKG in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IKBKG antibodies...
Designing a Western blot for IKBKG? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the IKBKG Western Blot GuideIKBKG Infographic by Boster Bio
All IKBKG Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00874
100 μl
Cat # M00874
100 μl
Human
$960
Cat # LS008517
20 µg, 100 µg
Cat # LS008517
20 µg, 100 µg
Human, Mouse, Rat
IHC, WB
$523
Cat # M00874-1
100 µl
Cat # M00874-1
100 µl
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A00874S31-1
100ul
Cat # A00874S31-1
100ul
Human
ELISA
$540
Cat # EKC2318
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2318
1 kit, containing two 96-well plates and all necessary reagents
Human
ELISA
$540
Cat # EKC2045
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2045
1 kit, containing two 96-well plates and all necessary reagents
Human
ELISA
$480
Cat # EKC1295
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1295
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA, IF, IHC
$380
Cat # A00874S376
100ul
Cat # A00874S376
100ul
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A00874S85
100ul
Cat # A00874S85
100ul
IKBKG Overview
Facts about NF-kappa-B essential modulator.
NF-kappa-B essential modulator (IKBKG)
Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus resulting in the dissociation of this inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin appears to play a part in IKK activation by multiple signaling receptor pathways.
However, the specific type of polyubiquitin recognized upon cell stimulation (either'Lys-63'- linked or linear polyubiquitin) and its functional significance is reported conflictingly. Also thought of as a mediator for TAX activation of NF-kappa-B.
Gene Information
| Human | |
|---|---|
| Gene Name: | IKBKG |
| Uniprot: | Q9Y6K9 |
| Entrez: | 8517 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
FIP-3IP2; FIP3NF-kappa-B essential modifier; FIP3P; I-kappa-B kinase subunit gamma; IkB kinase gamma subunit; IkB kinase subunit gamma; IkB kinase-associated protein 1; IKBKG; IKK gamma; IKKAP1; IKKG; IKK-gammaIPD2; incontinentia pigmenti; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; Inhibitor of nuclear factor kappa-B kinase subunit gamma; IP; IP1; NEMO; NEMOAMCBX1; NFkappaB essential modulator; NF-kappa-B essential modulator
Molecular Weight
Mass (kDA):
48.198 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xq28 |
| Sequence: | X; NC_000023.11 (154541238..154565046) |
Tissue Specificity
Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Subcellular Localizations
Cytoplasm. Nucleus. Sumoylated NEMO accumulates in the nucleus in response to genotoxic stress.
Diseases
- Bloch Sulzberger Syndrome
- Immunologic Deficiency Syndromes
- Ectodermal Dysplasia
- Dysplasia
- Inflammation
- Malignant Neoplasms
- Infective Disorder
- Neoplasms
- Anhydrotic Ectodermal Dysplasias
- Genetic Diseases, X-linked
- Christ-siemens-touraine Syndrome
- Bacterial Infections
- Nervousness
Interacting Proteins
- ADAP2
- AMOT
- ANXA1
- ARL6IP4
- ATM
- ATR
- BCL10
- CALB1
- CDC37
- CDK2
Pathways
- Cell Death
- Cell Proliferation
- Localization
- Pathogenesis
- Cytokinesis
- Transport
- Immune Response
- Abscission
- Cytokine Production
- Cell Cycle
- Pigmentation
- Translation
- Induction Of Apoptosis
PTMs
- Phosphorylation
- Ubiquitination
- Sumoylation
Research Areas
- Apoptosis
- Cancer
- Immunology
- Innate Immunity
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IKBKG
bosterbio.com/bosterbio-gene-info-cards/IKBKG
References
PMID: 9927690 by Li Y., et al. Identification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis.
PMID: 10087442 by Jin D.-Y., et al. Isolation of full-length cDNA and chromosomal localization of human NF-kappaB modulator NEMO to Xq28.