IL12RB1 Antibodies

AND IL12RB1 ELISA kits, IL12RB1 Proteins

Many biological assays use antibodies to detect IL12RB1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IL12RB1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IL12RB1 antibodies...

We validate the specificity of these antibodies to IL12RB1 by testing them on tissues known to express IL12RB1 positively and negatively. Browse below to find the IL12RB1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for IL12RB1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the IL12RB1 Western Blot Guide

IL12RB1 Infographic by Boster Bio

All IL12RB1 Products

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Product

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Specificity

Applications

Price

IL12RB1 (NM_005535) Human Over-expression Lysate

IL12RB1 Human Over-expression Lysates NM_005535

Human

$960
Cat # LS003594
20 µg, 100 µg

Anti-IL12RB1 Antibody Picoband®

Western blot analysis of IL12RB1 using anti-IL12RB1 antibody (A03401-1)

Human

$370
Cat # A03401-1
100 μg/vial

Human IL-12 R beta 1 Recombinant Protein

SDS-PAGE

$250
Cat # PROTP42701
Starting from 10ug

IL12RB1 Overview

Facts about Interleukin-12 receptor subunit beta-1.

IL12RB1 3D structure. Source: alphafold

Interleukin-12 receptor subunit beta-1 (IL12RB1)

Functions as an interleukin receptor that binds interleukin-12 with reduced affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, higher affinity receptor for IL12.

Associates also with IL23R to form the interleukin-23 receptor that functions in IL23 signal transduction likely through activation of the Jak-Stat signaling cascade. .

Gene Information

Human
Gene Name:	IL12RB1
Uniprot:	P42701
Entrez:	3594

Family

Belongs to:

type I cytokine receptor family

Alternative Names

CD212 antigen; CD212; IL-12 R beta 1; IL-12 receptor beta component; IL-12 receptor subunit beta-1; IL12R beta 1; IL-12R subunit beta-1; IL12R; IL12RB; IL12RB1; IL-12Rb1; IL-12R-BETA1; IL-12R-beta-1; interleukin 12 receptor, beta 1; interleukin-12 receptor beta-1 chain; interleukin-12 receptor subunit beta-1; MGC34454

Molecular Weight

Mass (kDA):
73.109 kDA

Genomic Context


Human

Location:	19p13.11
Sequence:	19; NC_000019.10 (18058994..18099027, complement)

Subcellular Localizations

Membrane; Single-pass type I membrane protein.

Diseases

Infective Disorder
Mycobacterium Infections
Tuberculosis
Salmonella Infections
Immunologic Deficiency Syndromes
Autoimmune Reaction
Inflammation
Autoimmune Diseases
Communicable Diseases
Malaria
Tuberculosis, Pulmonary
Neoplasms

Dysequilibrium Syndrome
Lymphadenitis
Encephalitis
Mycobacterium Avium-intracellulare Infection
Mycobacterium Infections, Nontuberculous
Nervousness
Lymphoma

Pathways

Pathogenesis
Immune Response
Secretion
Cell Activation
Cell Differentiation
T Cell Activation
Interferon-gamma Production
Inflammatory Response
Sensitization
Cell Cycle
Cell Proliferation
Cell Development
Localization

T Cell Differentiation
Viral Replication
Transport
Programmed Cell Death
Chemokine Production
Cytokine Secretion
Adaptive Immune Response

PTMs

Phosphorylation

Cleavage

Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IL12RB1

References

PMID: 7911493 by Chua A.O., et al. Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130.

PMID: 8943050 by Presky D.H., et al. A functional interleukin 12 receptor complex is composed of two beta- type cytokine receptor subunits.