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- Table of Contents
IL18RAP Antibodies
AND IL18RAP ELISA kits, IL18RAP Proteins
Many biological assays use antibodies to detect IL18RAP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IL18RAP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IL18RAP antibodies...
Designing a Western blot for IL18RAP? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the IL18RAP Western Blot GuideIL18RAP Infographic by Boster Bio
All IL18RAP Products
Product
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Specificity
Applications
Price
IL18RAP Overview
Facts about Interleukin-18 receptor accessory protein.
Interleukin-18 receptor accessory protein (IL18RAP)
Within the IL18 receptor complex, doesn't mediate IL18- binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation (PubMed:9792649, PubMed:14528293, PubMed:25500532). May play a role in IL18- mediated IFNG synthesis from T-helper 1 (Th1) cells (Probable).
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Gene Information
| Human | |
|---|---|
| Gene Name: | IL18RAP |
| Uniprot: | O95256 |
| Entrez: | 8807 |
Family
| Belongs to: |
|---|
| interleukin-1 receptor family |
Alternative Names
CD218a; IL-1 R5; IL-1 Rrp; IL-18 R alpha; IL-18 R1; IL18R alpha; IL18R1; IL-18Ra
Molecular Weight
Mass (kDA):
68.31 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q12.1 |
| Sequence: | 2; NC_000002.12 (102418550..102452568) |
Tissue Specificity
Detected in adrenal gland, bone marrow, brain, fetal brain, fetal liver, heart, kidney, lung, liver, peripheral blood leukocytes, placenta, prostate, salivary gland, skeletal muscle, spinal cord, testis, thymus, thyroid, trachea and uterus (PubMed:17897836). Strongly expressed in peripheral blood leukocytes and spleen and, to a lesser extent, in colon (PubMed:9792649). Specifically coexpressed with IL18R1 in T-helper 1 (Th1)cells (PubMed:10925275, PubMed:11046021, PubMed:10653850).
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein.
Diseases
- Inflammation
- Neoplasms
- Rheumatoid Arthritis
- Autoimmune Reaction
- Arthritis
- Asthma
- Autoimmune Diseases
- Infective Disorder
- Malignant Neoplasms
- Degenerative Polyarthritis
- Innate Immune Response
- Autoimmunity
- Tissue Adhesions
Pathways
- Immune Response
- Pathogenesis
- Secretion
- Cytokine Production
- Cell Proliferation
- Cell Activation
- Interferon-gamma Production
- Innate Immune Response
- Cell Development
- T Cell Activation
- Cell Differentiation
- Histone Acetylation
- Inflammatory Response
PTMs
- Phosphorylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IL18RAP
bosterbio.com/bosterbio-gene-info-cards/IL18RAP
References
PMID: 9792649 by Born T.L., et al. Cloning of a novel receptor subunit, AcPL, required for interleukin- 18 signaling.
PMID: 17897836 by Fiszer D., et al. Identification of IL-18RAP mRNA truncated splice variants in human testis and the other human tissues.
1 Publications of Boster IL18RAP Antibodies & ELISA Kits
- PubMed ID: 10.1016/j.exer.2021.108750, Wedelolactone ameliorates Pseudomonas aeruginosa-induced inflammation and cornea...
*More publications can be found for each product on its corresponding product page