Interleukin-1 receptor-like 2 (IL1RL2)

Receptor for interleukin-36 (IL36A, IL36B and IL36G).

After binding to interleukin-36 partners with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity).

The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL- 23/IL-17/IL-22 pathway.