IL22RA2 Antibodies

AND IL22RA2 ELISA kits, IL22RA2 Proteins

Many biological assays use antibodies to detect IL22RA2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IL22RA2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IL22RA2 antibodies...

We validate the specificity of these antibodies to IL22RA2 by testing them on tissues known to express IL22RA2 positively and negatively. Browse below to find the IL22RA2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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IL22RA2 Infographic by Boster Bio

All IL22RA2 Products

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Specificity

Applications

Price

Anti-IL-22R Alpha 2 IL22RA2 Antibody

Western blot (WB) analysis of IL-22Rα2 polyclonal antibody at 1:500 dilution
Lane1:MCF-7 cell lysate
Lane2:Mouse heart tissue lysate
Lane3:Rat heart tissue lysate

Human, Mouse, Rat

$405
Cat # A06250
100ul

IL22 RA2 (IL22RA2) (NM_181309) Human Over-expression Lysate

Human

$628
Cat # LS116379
20 µg, 100 µg

IL22RA2 Overview

Facts about Interleukin-22 receptor subunit alpha-2.

IL22RA2 3D structure. Source: alphafold

Interleukin-22 receptor subunit alpha-2 (IL22RA2)

Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the operational IL-22R complicated and blocks the action of IL22 (in vitro).

May play an important role as an IL22 antagonist in the regulation of inflammatory reactions. .

Gene Information

Human
Gene Name:	IL22RA2
Uniprot:	Q969J5
Entrez:	116379

Family

Belongs to:

type II cytokine receptor family

Alternative Names

class II cytokine receptor; CRF2-10; CRF2-S1IL22BP; CRF2-X; Cytokine receptor class-II member 10; Cytokine receptor family 2 member 10; Cytokine receptor family type 2, soluble 1; IL-22 RA2; IL-22 receptor subunit alpha-2; IL22BP; IL-22BP; IL-22BPCRF2X; IL22RA2; IL-22RA2; IL-22R-alpha-2; interleukin 22 receptor, alpha 2; interleukin 22-binding protein; interleukin-22 receptor subunit alpha-2; Interleukin-22-binding protein; MGC150509; MGC150510; zcytoR16

Molecular Weight

Mass (kDA):
30.55 kDA

Genomic Context


Human

Location:	6q23.3
Sequence:	6; NC_000006.12 (137143820..137173644, complement)

Tissue Specificity

Expressed in placenta, spleen, breast, skin and lung. Also detected in intestinal tract, testis, brain, heart and thymus. No expression found in prostate, bladder, kidney, ovary, muscle, bone marrow, liver and uterus. Isoform 1 is expressed only in placenta. Isoform 2 is expressed in placenta and breast and at lower level in spleen, skin, thymus and stomach.

Subcellular Localizations

Secreted.

Diseases

Inflammation
Malignant Neoplasms
Neoplasms
Rhinorrhea
Sclerosis
Melanoma
Polyps
Inflammatory Bowel Diseases
Intestinal Diseases
Malignant Neoplasm Of Lung
Inflammatory Response

Carcinoma
Insulin Resistance
Innate Immune Response
Colorectal Cancer
Chronic Lymphocytic Leukemia
Tissue Damage

Pathways

Pathogenesis
Leukocyte Activation
Cell Proliferation
Keratinocyte Proliferation
Wound Healing
Localization
Epithelial Cell Proliferation

Inflammatory Response

PTMs

Phosphorylation

Research Areas

Cytokine Research
Immunology
Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IL22RA2

References

PMID: 11607789 by Gruenberg B.H., et al. A novel, soluble homologue of the human IL-10 receptor with preferential expression in placenta.

PMID: 11390454 by Kotenko S.V., et al. Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity.