Interleukin-4 receptor subunit alpha (IL4R)

Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway.

The IL4 response is included in promoting Th2 differentiation. The IL4/IL13 responses are included in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation.