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ING1 Antibodies
AND ING1 ELISA kits, ING1 Proteins
Many biological assays use antibodies to detect ING1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ING1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ING1 antibodies...
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ING1 Infographic by Boster Bio
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ING1 Overview
Facts about Inhibitor of growth protein 1.
Inhibitor of growth protein 1 (ING1)
Cooperates with p53/TP53 from the regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | ING1 |
| Uniprot: | Q9UK53 |
| Entrez: | 3621 |
Family
| Belongs to: |
|---|
| ING family |
Alternative Names
growth inhibitor ING1; growth inhibitory protein ING1; ING1; inhibitor of growth family, member 1; inhibitor of growth protein 1; p24ING1c; p33; p33ING1; p33ING1b; p47; p47ING1a; tumor suppressor ING1
Molecular Weight
Mass (kDA):
46.738 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 13q34 |
| Sequence: | 13; NC_000013.11 (110712623..110723339) |
Tissue Specificity
Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines.
Subcellular Localizations
Nucleus.
Diseases
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Cell Transformation, Neoplastic
- Malignant Squamous Cell Neoplasm
- Carcinogenesis
- Melanoma
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Breast
- Liver Carcinoma
- Mammary Neoplasms
- Liver Neoplasms
- Adenocarcinoma
Interacting Proteins
- NQO1
Pathways
- Cell Cycle
- Dna Repair
- Senescence
- Cell Growth
- Cell Cycle Arrest
- Localization
- Cell Death
- Cell Proliferation
- Cellular Senescence
- Chromatin Remodeling
- Pathogenesis
- Histone Acetylation
- Methylation
PTMs
- Acetylation
- Methylation
- Deacetylation
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ING1
bosterbio.com/bosterbio-gene-info-cards/ING1
References
PMID: 8944021 by Garkavtsev I.A., et al. Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation.
PMID: 10626813 by Jaeger D., et al. Cancer-testis antigens and ING1 tumor suppressor gene product are breast cancer antigens: characterization of tissue-specific ING1 transcripts and a homologue gene.