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INSM1 Antibodies
AND INSM1 ELISA kits, INSM1 Proteins
Many biological assays use antibodies to detect INSM1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with INSM1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop INSM1 antibodies...
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INSM1 Infographic by Boster Bio
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INSM1 Overview
Facts about Insulinoma-associated protein 1.
Insulinoma-associated protein 1 (INSM1)
Sequence-specific DNA-binding transcriptional regulator that plays an integral role in neurogenesis and neuroendocrine cell differentiation during embryonic or fetal development. Binds to the consensus sequence 5'-[TG][TC][TC][TT][GA]GGG[CG]A-3' in target promoters.
Acts as a transcriptional repressor of NEUROD1 and INS expression via its interaction with cyclin CCND1 in a cell cycle-independent manner. Negatively regulates skeletal muscle- specific gene expression in endocrine cells of the pituitary by inhibiting the Notch signaling pathway.
Gene Information
| Human | |
|---|---|
| Gene Name: | INSM1 |
| Uniprot: | Q01101 |
| Entrez: | 3642 |
Family
| Belongs to: |
|---|
| INSM1 family |
Alternative Names
IA1IA-1; insulinoma-associated 1; insulinoma-associated protein 1; Zinc finger protein IA-1
Molecular Weight
Mass (kDA):
52.923 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 20p11.23 |
| Sequence: | 20; NC_000020.11 (20368104..20370949) |
Tissue Specificity
Expressed in pancreatic duct cells. Expressed in several tumor cell lines of neuroendocrine origin including pheochromocytoma, medullary thyroid carcinoma, insulinoma, medulloblastoma, retinoblastoma, pheochromacytoma, medullary thyroid carcinoma and small cell lung carcinoma.
Subcellular Localizations
Nucleus.
Diseases
- Neoplasms
- Malignant Neoplasms
- Insulinoma
- Nervousness
- Neuroendocrine Tumors
- Medulloblastoma
- Small Cell Carcinoma Of Lung
- Malignant Neoplasm Of Lung
- Lung Neoplasms
- Diabetes Mellitus
- Cancer Patients And Suicide And Depression
- Malignant Paraganglionic Neoplasm
Pathways
- Cell Differentiation
- Neurogenesis
- Cell Cycle
- Mitosis
- Cell Cycle Arrest
- Localization
- Pancreas Development
- Cell Development
- Neuroendocrine Cell Differentiation
- Methylation
- Generation Of Neurons
- Secretion
- Transport
PTMs
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/INSM1
bosterbio.com/bosterbio-gene-info-cards/INSM1
References
PMID: 1634555 by Goto Y., et al. A novel human insulinoma-associated cDNA, IA-1, encodes a protein with 'zinc-finger' DNA-binding motifs.
PMID: 8188699 by Lan M.S., et al. Genomic organization, 5'-upstream sequence, and chromosomal localization of an insulinoma-associated intronless gene, IA-1.