INTS3 Antibodies

AND INTS3 ELISA kits, INTS3 Proteins

Many biological assays use antibodies to detect INTS3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with INTS3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop INTS3 antibodies...

We validate the specificity of these antibodies to INTS3 by testing them on tissues known to express INTS3 positively and negatively. Browse below to find the INTS3 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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INTS3 Infographic by Boster Bio

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Anti-INTS3 antibody

Human, Mouse, Rat

ELISA, IP, WB

$370
Cat # A08682-1
100 μl/vial

INTS3 Overview

Facts about Integrator complex subunit 3.

INTS3 3D structure. Source: alphafold

Integrator complex subunit 3 (INTS3)

Part of the Integrator (INT) Complicated.
The Integrator complex is included in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.

The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, likely as part of the INT complicated (PubMed:23904267).

Gene Information

Human
Gene Name:	INTS3
Uniprot:	Q68E01
Entrez:	65123

Family

Belongs to:

Integrator subunit 3 family

Alternative Names

C1orf193; C1orf60; chromosome 1 open reading frame 60; DKFZp686E1950; DKFZp686O20115; DKFZp781I1253; FLJ21919; FLJ44849; INT3; integrator complex subunit 3; RP11-216N14.4; Sensor of single-strand DNA complex subunit A; sensor of ssDNA A; Sensor of ssDNA subunit A; SOSS complex subunit A; SOSS-A

Molecular Weight

Mass (kDA):
118.07 kDA

Genomic Context


Human

Location:	1q21.3
Sequence:	1; NC_000001.11 (153728050..153774808)

Subcellular Localizations

Nucleus. Cytoplasm. Localizes to nuclear foci following DNA damage.

Diseases

Neoplasms
Liver Carcinoma
Ataxia
Liver Neoplasms
Genomic Instability
Carcinoma

Interacting Proteins

INIP
NABP1
NABP2
NBN
ZBTB14

Pathways

Recombinational Repair
Dna Replication
Hypersensitivity

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/INTS3

References

PMID: 16239144 by Baillat D., et al. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II.

PMID: 19605351 by Li Y., et al. hSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response.