INTS7 Antibodies

AND INTS7 ELISA kits, INTS7 Proteins

Many biological assays use antibodies to detect INTS7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with INTS7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop INTS7 antibodies...

We validate the specificity of these antibodies to INTS7 by testing them on tissues known to express INTS7 positively and negatively. Browse below to find the INTS7 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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INTS7 Infographic by Boster Bio

All INTS7 Products

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Product

Figures

Specificity

Applications

Price

INTS7 (NM_015434) Human Over-expression Lysate

Human

$628
Cat # LS025896
20 µg, 100 µg

Anti-INTS7 Antibody

Human, Mouse, Rat

ELISA, IF, IHC, ICC, WB

$370
Cat # A11614-1
100 μl/vial

INTS7 Overview

Facts about Integrator complex subunit 7.

INTS7 3D structure. Source: alphafold

Integrator complex subunit 7 (INTS7)

Part of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable).

Plays a role in DNA damage response (DDR) signaling during the S phase (PubMed:21659603). May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex (PubMed:23904267).

Gene Information

Human
Gene Name:	INTS7
Uniprot:	Q9NVH2
Entrez:	25896

Family

Belongs to:

Integrator subunit 7 family

Alternative Names

C1orf73; chromosome 1 open reading frame 73; DKFZp434B168; INT7; integrator complex subunit 7

Molecular Weight

Mass (kDA):
106.834 kDA

Genomic Context


Human

Location:	1q32.3
Sequence:	1; NC_000001.11 (211940328..212035660, complement)

Subcellular Localizations

Nucleus. Chromosome. Cytoplasm. Localizes to sites of DNA damage in a H2AX-independent manner.

Diseases

Fanconi Anemia
Ataxia Telangiectasia
Anemia
Telangiectasis
Ataxia

Interacting Proteins

Pathways

Snrna Processing
Dna Replication
Cell Proliferation
Cell Cycle
Dna Repair
Regulation Of Gene Expression
Rna Processing

Cell Cycle Arrest

PTMs

Phosphoprotein

Research Areas

Zinc Finger

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/INTS7

References

PMID: 16239144 by Baillat D., et al. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II.

PMID: 21659603 by Cotta-Ramusino C., et al. A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling.