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- Table of Contents
Integrin alpha-3 Antibodies
AND ITGA3 ELISA kits, Integrin alpha-3 Proteins
Many biological assays use antibodies to detect Integrin alpha-3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Integrin alpha-3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Integrin alpha-3 antibodies...
Designing a Western blot for Integrin alpha-3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ITGA3 Western Blot GuideITGA3 Infographic by Boster Bio
All ITGA3 Products
Product
Figures
Specificity
Applications
Price
Anti-Integrin alpha 3/ITGA3 Antibody Picoband®
3 Citations
Human, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PA1621
100 μg/vial
Cat # PA1621
100 μg/vial
Anti-Integrin alpha 3/ITGA3 Antibody Picoband®
2 Citations
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A02902
100 μg/vial
Cat # A02902
100 μg/vial
Human
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A02902-1
100 μg/vial
Cat # A02902-1
100 μg/vial
Human
$960
Cat # LS003675
20 µg, 100 µg
Cat # LS003675
20 µg, 100 µg
Human
Flow Cytometry, IP, IHC-F, WB
$299
Cat # M02902
0.1 mg
Cat # M02902
0.1 mg
ITGA3 Overview
Facts about Integrin alpha-3.
Integrin alpha-3 (ITGA3)
Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes at a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion.
Alpha- 3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. .
Gene Information
| Human | |
|---|---|
| Gene Name: | ITGA3 |
| Uniprot: | P26006 |
| Entrez: | 3675 |
Family
| Belongs to: |
|---|
| integrin alpha chain family |
Alternative Names
antigen identified by monoclonal J143; CD49 antigen-like family member C; CD49c antigen; CD49c; FLJ34631; FLJ34704; FRP-2; Galactoprotein B3; GAP-B3; GAPB3CD49C; Integrin alpha 3; integrin alpha-3; integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor); ITGA3; MSK18; VCA-2; very late activation protein 3 receptor, alpha-3 subunit; VL3A; VLA-3 subunit alpha; VLA3a
Molecular Weight
Mass (kDA):
116.612 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q21.33 |
| Sequence: | 17; NC_000017.11 (50056065..50090481) |
Tissue Specificity
Isoform 1 is widely expressed. Isoform 2 is expressed in brain and heart. In brain, both isoforms are exclusively expressed on vascular smooth muscle cells, whereas in heart isoform 1 is strongly expressed on vascular smooth muscle cells, isoform 2 is detected only on endothelial vein cells.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell projection, invadopodium membrane; Single-pass type I membrane protein. Cell projection, filopodium membrane; Single-pass type I membrane protein. Enriched preferentially at invadopodia, cell membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner.
Diseases
- Malignant Neoplasms
- Neoplasms
- Neoplasm Metastasis
- Tissue Adhesions
- Carcinoma
- Malignant Squamous Cell Neoplasm
- Cell Invasion
- Cell Transformation, Neoplastic
- Adenocarcinoma
- Nephrotic Syndrome
- Stomach Neoplasms
- Metastatic Malignant Neoplasm To The Lymph Node
Interacting Proteins
- CD151
Pathways
- Cell Proliferation
- Cell Adhesion
- Regulation Of Biological Process
- Reproductive Process
- Skin Development
- Inner Ear Development
- Embryo Development
- Blastocyst Formation
- Axon Guidance
- Cell Cycle
- Multicellular Organismal Process
- Wound Healing
- Cell-cell Adhesion
PTMs
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ITGA3
bosterbio.com/bosterbio-gene-info-cards/ITGA3
References
PMID: 1655803 by Takada Y., et al. Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen.
PMID: 1714443 by Tsuji T., et al. Identification of human galactoprotein b3, an oncogenic transformation-induced membrane glycoprotein, as VLA-3 alpha subunit: the primary structure of human integrin alpha 3.
1 Publications of Boster Integrin alpha-3 Antibodies & ELISA Kits
- PubMed ID: 32544337, Li H,Yuan L,Long Y,Fang H,Li M,Liu Q,Xia X,Qin C,Zhang Y,Lan X,Gai Y.Synthesis a...
*More publications can be found for each product on its corresponding product page