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- Table of Contents
Integrin alpha-8 Antibodies
AND ITGA8 ELISA kits, Integrin alpha-8 Proteins
Many biological assays use antibodies to detect Integrin alpha-8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Integrin alpha-8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Integrin alpha-8 antibodies...
Designing a Western blot for Integrin alpha-8? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ITGA8 Western Blot GuideDesigning an IHC experiment for Integrin alpha-8? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the ITGA8 IHC GuideITGA8 Infographic by Boster Bio
All ITGA8 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A06636-2
100 µg/vial
Cat # A06636-2
100 µg/vial
ITGA8 Overview
Facts about Integrin alpha-8.
Integrin alpha-8 (ITGA8)
Integrin alpha-8/beta-1 works from the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells to epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands such as TNC, FN1, SPP1 TGFB1, TGFB3 and VTN.
NPNT is likely its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and modulates neurite outgrowth of sensory and motor neurons.
Gene Information
| Human | |
|---|---|
| Gene Name: | ITGA8 |
| Uniprot: | P53708 |
| Entrez: | 8516 |
Family
| Belongs to: |
|---|
| integrin alpha chain family |
Alternative Names
Integrin alpha 8; integrin alpha-8; integrin, alpha 8; ITGA8
Molecular Weight
Mass (kDA):
117.474 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10p13 |
| Sequence: | 10; NC_000010.11 (15513949..15720335, complement) |
Tissue Specificity
Expressed in mesenchymal cells, including alveolar myofibroblasts, kidney mesangial cells and hepatic stellar cells and vascular and visceral smooth muscle (at protein level).
Subcellular Localizations
Membrane; Single-pass type I membrane protein. Cell membrane.
Diseases
- Tissue Adhesions
- Hypertensive Disease
- Cholangiocarcinoma
- Essential Hypertension
- Cardiac Hypertrophy
- Labyrinthine Disorder
- Endometrial Polyp
- Sensation Disorders
- Lung Diseases
- Parkinson Disease
- Injury To Kidney
- Fibrosis
Pathways
- Cell Adhesion
- Tissue Remodeling
- Lung Development
- Methylation
- Cell Migration
- Gastrulation
- Dna Methylation
- Localization
- Demethylation
- Embryo Development
- Blastocyst Formation
PTMs
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ITGA8
bosterbio.com/bosterbio-gene-info-cards/ITGA8
References
PMID: 7768999 by Schnapp L.M., et al. Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells.
PMID: 10504498 by Hartner A., et al. Alpha8 integrin in glomerular mesangial cells and in experimental glomerulonephritis.