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- Table of Contents
Integrin alpha-L Antibodies
AND ITGAL ELISA kits, Integrin alpha-L Proteins
Many biological assays use antibodies to detect Integrin alpha-L, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Integrin alpha-L in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Integrin alpha-L antibodies...
Designing a Western blot for Integrin alpha-L? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ITGAL Western Blot GuideITGAL Infographic by Boster Bio
All ITGAL Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M04466-1
100 μl
Cat # M04466-1
100 μl
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M04466-4
100 μg
Cat # M04466-4
100 μg
ITGAL Overview
Facts about Integrin alpha-L.
Integrin alpha-L (ITGAL)
Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4.
Integrin alpha-L/beta-2 is also a receptor for F11R (PubMed:11812992, PubMed:15528364).Involved in many different immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity (PubMed:15356110).
Gene Information
| Human | |
|---|---|
| Gene Name: | ITGAL |
| Uniprot: | P20701 |
| Entrez: | 3683 |
Family
| Belongs to: |
|---|
| integrin alpha chain family |
Alternative Names
CD11 antigen-like family member A; CD11a antigen; CD11a; CD11Aantigen CD11A (p180), lymphocyte function-associated antigen 1, alphapolypeptide; Integrin alpha L; integrin alpha-L; integrin gene promoter; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen1; alpha polypeptide); ITGAL; Leukocyte adhesion glycoprotein LFA-1 alpha chain; Leukocyte function-associated molecule 1 alpha chain; LFA-1 alpha; LFA-1; LFA1A; LFA-1A; Ly-15; Ly-21; lymphocyte function-associated antigen 1
Molecular Weight
Mass (kDA):
128.77 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16p11.2 |
| Sequence: | 16; NC_000016.10 (30472683..30523185) |
Tissue Specificity
Leukocytes.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein.
Diseases
- Tissue Adhesions
- Lupus Erythematosus, Systemic
- Malignant Neoplasms
- Inflammation
- Autoimmune Reaction
- Neoplasms
- Inflammatory Bowel Diseases
- Intestinal Diseases
- Autoimmune Diseases
- Autoimmunity
- Sclerosis
- Atresia
- Hepatitis B
Interacting Proteins
- ICAM1
- PTPRC
Pathways
- Dna Methylation
- Methylation
- Pathogenesis
- Demethylation
- Dna Hypomethylation
- Cell Adhesion
- Immune Response
- Secretion
- Response To Stress
- Dna Hypermethylation
- Aging
PTMs
- Methylation
Research Areas
- Adaptive Immunity
- Cytokine Research
- Immunology
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ITGAL
bosterbio.com/bosterbio-gene-info-cards/ITGAL
References
PMID: 2537322 by Larson R.S., et al. Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily.
PMID: 8099450 by Shelley C.S., et al. Identification of cell-specific and developmentally regulated nuclear factors that direct myeloid and lymphoid expression of the CD11a gene.
2 Publications of Boster Integrin alpha-L Antibodies & ELISA Kits
- PubMed ID: 10.1016/j.ejphar.2005.12.080, Protective effect of bicyclol on acute hepatic failure induced by lipopolysaccha...
- PubMed ID: 25691929, Mu L, Jing C, Guo Z. Iran J Basic Med Sci. 2014 Nov;17(11):874-8. Expressions Of...
*More publications can be found for each product on its corresponding product page