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- Table of Contents
ITPR1 Antibodies
AND ITPR1 ELISA kits, ITPR1 Proteins
Many biological assays use antibodies to detect ITPR1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ITPR1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ITPR1 antibodies...
Designing a Western blot for ITPR1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ITPR1 Western Blot GuideITPR1 Infographic by Boster Bio
All ITPR1 Products
Product
Figures
Specificity
Applications
Price
Anti-IP3 receptor/ITPR1 Antibody Picoband®
2 Citations
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB9225
100 μg/vial
Cat # PB9225
100 μg/vial
Anti-IP3 Receptor Rabbit Monoclonal Antibody
1 Citations
Human, Mouse, Rat
IP, IHC, WB
$370
Cat # M01465-1
100 μl/vial
Cat # M01465-1
100 μl/vial
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A01465S1764
100ul
Cat # A01465S1764
100ul
Human, Mouse, Rat
ELISA, IF, IHC
$380
Cat # A01465S1598
100ul
Cat # A01465S1598
100ul
ITPR1 Overview
Facts about Inositol 1,4,5-trisphosphate receptor type 1.
Inositol 1,4,5-trisphosphate receptor type 1 (ITPR1)
Intracellular channel that mediates calcium release from the endoplasmic reticulum after stimulation by inositol 1,4,5- trisphosphate (PubMed:27108797). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity).
Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | ITPR1 |
| Uniprot: | Q14643 |
| Entrez: | 3708 |
Family
| Belongs to: |
|---|
| InsP3 receptor family |
Alternative Names
DKFZp313E1334; DKFZp313N1434; inositol 14,5-triphosphate receptor, type 1; inositol 14,5-trisphosphate receptor type 1; INSP3R1; IP3 receptor isoform 1; IP3 receptor; IP3R 1; IP3R; IP3R1; SCA15; SCA16; spinocerebellar ataxia 15; spinocerebellar ataxia 16; Type 1 inositol 14,5-trisphosphate receptor; Type 1 InsP3 receptor
Molecular Weight
Mass (kDA):
313.929 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p26.1 |
| Sequence: | 3; NC_000003.12 (4493348..4847840) |
Tissue Specificity
Widely expressed.
Subcellular Localizations
Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region. Endoplasmic reticulum and secretory granules (By similarity).
Diseases
- Neuroblastoma
- Ataxia
- Ataxia, Spinocerebellar
- Cerebellar Ataxia
- Alzheimer's Disease
- Nervousness
- Neurodegenerative Disorders
- Malignant Neoplasms
- Atrophy
- Nerve Degeneration
- Carcinoma
- Neoplasms
Interacting Proteins
- AKT1
- VDAC1
Pathways
- Localization
- Secretion
- Cell Death
- Fertilization
- Transport
- Exocytosis
- Pathogenesis
- Cell Activation
- Oocyte Maturation
- Sensitization
- Proteolysis
- Cell Cycle
- T Cell Activation
PTMs
- Phosphorylation
- Dephosphorylation
- Cleavage
- Ubiquitination
- Methylation
- Nitration
Research Areas
- Neuroscience
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ITPR1
bosterbio.com/bosterbio-gene-info-cards/ITPR1
References
PMID: 7945203 by Yamada N., et al. Human inositol 1,4,5-trisphosphate type-1 receptor, InsP3R1: structure, function, regulation of expression and chromosomal localization.
PMID: 7852357 by Harnick D.J., et al. The human type 1 inositol 1,4,5-trisphosphate receptor from T lymphocytes. Structure, localization, and tyrosine phosphorylation.
3 Publications of Boster ITPR1 Antibodies & ELISA Kits
- PubMed ID: 10.1155/2021/8493431, LncRNA LINC00662 Exerts an Oncogenic Effect on Osteosarcoma by the miR-16-5p/ITP...
- PubMed ID: 33203874, Ma WQ,Sun XJ,Zhu Y,Liu NF. PDK4 promotes vascular calcification by interfering w...
- PubMed ID: 23437066, Neuroprotective Effect of Kaempferol Glycosides against Brain Injury and Neuroin...
*More publications can be found for each product on its corresponding product page