This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
IFNAR1 Antibodies
AND IFNAR1 ELISA kits, IFNAR1 Proteins
Many biological assays use antibodies to detect IFNAR1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IFNAR1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IFNAR1 antibodies...
Designing a Western blot for IFNAR1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the IFNAR1 Western Blot GuideIFNAR1 Infographic by Boster Bio
All IFNAR1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00306-5
100 μg
Cat # M00306-5
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00306-4
100 μg
Cat # M00306-4
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00306-6
100 μg
Cat # M00306-6
100 μg
Human
Flow Cytometry, IP, WB
$370
Cat # M00306-1
100 μl
Cat # M00306-1
100 μl
IFNAR1 Overview
Facts about Interferon alpha/beta receptor 1.
Interferon alpha/beta receptor 1 (IFNAR1)
Part of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:2153461, PubMed:7665574, PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:21854986). Functions generally as heterodimer with IFNAR2 (PubMed:7665574, PubMed:10049744, PubMed:21854986).
Type I interferon binding activates the JAK-STAT signaling cascade, and activates tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (PubMed:7665574, PubMed:21854986). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | IFNAR1 |
| Uniprot: | P17181 |
| Entrez: | 3454 |
Family
| Belongs to: |
|---|
| type II cytokine receptor family |
Alternative Names
alpha-type antiviral protein; AVP; beta-type antiviral protein; CRF2-1; Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; human interferon-alpha receptor (HuIFN-alpha-Rec)10IFRC; IFN-alpha/beta R1; IFN-alpha/beta receptor 1; IFN-alpha-REC; IFNAR; IFNAR1; IFN-aR1; IFNBR; IFNbR1; IFN-bR1; IFN-R-1; interferon (alpha, beta and omega) receptor 1; interferon alpha/beta receptor 1; interferon-alpha/beta receptor alpha chain; interferon-beta receptor 1; Type I interferon receptor 1
Molecular Weight
Mass (kDA):
63.525 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 21q22.11 |
| Sequence: | 21; NC_000021.9 (33324443..33360361) |
Tissue Specificity
IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R.
Subcellular Localizations
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Late endosome. Lysosome. Interferon binding triggers internalization of the receptor from the cell membrane into endosomes and then into lysosomes.
Diseases
- Virus Diseases
- Hepatitis
- Infective Disorder
- Janiceps
- Neoplasms
- Hepatitis C
- Inflammation
- Multiple Sclerosis
- Sclerosis
- Hepatitis, Chronic
- Malignant Neoplasms
- Innate Immune Response
- Hepatitis C, Chronic
Interacting Proteins
- FBXW11
- STAT1
- STAT2
- TYK2
Pathways
- Immune Response
- Pathogenesis
- Viral Replication
- Secretion
- Innate Immune Response
- Cell Proliferation
- Endocytosis
- Cell Death
- Cell Cycle
- Localization
- Cell Activation
- Virulence
- Inflammatory Response
PTMs
- Phosphorylation
- Ubiquitination
- Methylation
- Glycosylation
- Dephosphorylation
Research Areas
- Neuroscience
- Phospho-Specific
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IFNAR1
bosterbio.com/bosterbio-gene-info-cards/IFNAR1
References
PMID: 2153461 by Uze G., et al. Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA.
PMID: 1370833 by Lutfalla G., et al. The structure of the human interferon alpha/beta receptor gene.
4 Publications of Boster IFNAR1 Antibodies & ELISA Kits
- PubMed ID: 10.1080/08820139.2016.1248561, Vinpocetine Inhibited the CpG Oligodeoxynucleotide-induced Immune Response in Pl...
- PubMed ID: 10.1016/j.yexcr.2016.10.020, Coxsackievirus B3 induces the formation of autophagosomes in cardiac fibroblasts...
- PubMed ID: 10.1016/j.colsurfb.2016.04.037, Preparation and characterization of latex films photo-immobilized with IFN-α
- PubMed ID: -, WEI Wen-Long,WU Shi-Fei,LI Hao-Jv,LI Zhen-Wei,QU Hua,YAO Chang-Liang,ZHANG Jian-...
*More publications can be found for each product on its corresponding product page