Protein Jade-1 (JADE1)

Part of the HBO1 complex that has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5.

Promotes apoptosis. May act as a renal tumor suppressor.