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JAK1 Antibodies
AND JAK1 ELISA kits, JAK1 Proteins
Many biological assays use antibodies to detect JAK1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with JAK1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop JAK1 antibodies...
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JAK1 Infographic by Boster Bio
All JAK1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA
$540
Cat # EKC2440
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2440
1 kit, containing two 96-well plates and all necessary reagents
Human
IHC, WB
$370
Cat # M00330Y1034Y1035
100 µl/vial
Cat # M00330Y1034Y1035
100 µl/vial
JAK1 Overview
Facts about Tyrosine-protein kinase JAK1.
Tyrosine-protein kinase JAK1 (JAK1)
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529).
.
Gene Information
| Human | |
|---|---|
| Gene Name: | JAK1 |
| Uniprot: | P23458 |
| Entrez: | 3716 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.10; Jak1; JAK-1; JAK1Atyrosine-protein kinase JAK1; JAK1B; Janus kinase 1EC 2.7.10.2; JTK3
Molecular Weight
Mass (kDA):
133.277 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p31.3 |
| Sequence: | 1; NC_000001.11 (64833223..65067746, complement) |
Tissue Specificity
Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue.
Subcellular Localizations
Endomembrane system; Peripheral membrane protein. Wholly intracellular, possibly membrane associated.
Diseases
- Janiceps
- Malignant Neoplasms
- Neoplasms
- Leukemia
- Carcinoma
- Inflammation
- Cell Transformation, Neoplastic
- Liver Carcinoma
- Tissue Adhesions
- Primary Myelofibrosis
- Immunologic Deficiency Syndromes
- Lymphoma
- Myeloid Leukemia
Interacting Proteins
- ERBB2
- IFNAR2
- JAK2
Pathways
- Cell Proliferation
- Pathogenesis
- Cell Growth
- Secretion
- Cell Cycle
- Cell Death
- Immune Response
- Localization
- Induction Of Apoptosis
- Cell Migration
- Angiogenesis
- Cell Differentiation
- Regeneration
PTMs
- Phosphorylation
- Dephosphorylation
- Cleavage
- Methylation
- Ubiquitination
- Isgylation
- Demethylation
- Glutathionylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/JAK1
bosterbio.com/bosterbio-gene-info-cards/JAK1
References
PMID: 1848670 by Wilks A.F., et al. Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase.
PMID: 8247543 by Lee S.-T., et al. A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes.
3 Publications of Boster JAK1 Antibodies & ELISA Kits
- PubMed ID: 10.3892/ijmm.2018.3419, Hydrogen sulfide attenuates myocardial fibrosis in diabetic rats through the JAK...
- PubMed ID: 30747218, Zhang T,Ma L,Wu P,Li W,Li T,Gu R,Dan X,Li Z,Fan X,Xiao Z.Gallic acid has antican...
- PubMed ID: 29393353, Hydrogen sulfide attenuates myocardial fibrosis in diabetic rats through the JAK...
*More publications can be found for each product on its corresponding product page