Immunoglobulin J chain Antibodies

AND JCHAIN ELISA kits, Immunoglobulin J chain Proteins

Many biological assays use antibodies to detect Immunoglobulin J chain, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Immunoglobulin J chain in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Immunoglobulin J chain antibodies...

We validate the specificity of these antibodies to Immunoglobulin J chain by testing them on tissues known to express JCHAIN positively and negatively. Browse below to find the JCHAIN antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for Immunoglobulin J chain? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the JCHAIN IHC Guide

JCHAIN Infographic by Boster Bio

All JCHAIN Products

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Product

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Specificity

Applications

Price

Anti-JCHAIN Antibody Picoband®

Western blot analysis of JCHAIN using anti-JCHAIN antibody (A02644-2)

IHC analysis of JCHAIN using anti-JCHAIN antibody (A02644-2)

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A02644-2
100 µg/vial

IGJ (JCHAIN) (NM_144646) Human Over-expression Lysate

Human

$628
Cat # LS003512
20 µg, 100 µg

IGJ (JCHAIN) (NM_144646) Human Recombinant Protein

Coomassie blue staining of purified JCHAIN protein

$1062
Cat # PROTP01591
20 µg

JCHAIN Overview

Facts about Immunoglobulin J chain.

JCHAIN 3D structure. Source: alphafold

Immunoglobulin J chain (JCHAIN)

Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers.

It also help bind these immunoglobulins to secretory component. .

Gene Information

Human
Gene Name:	JCHAIN
Uniprot:	P01591
Entrez:	3512

Family

Belongs to:

No superfamily

Alternative Names

IGCJJCH; immunoglobulin J chain; immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mupolypeptides

Molecular Weight

Mass (kDA):
18.099 kDA

Genomic Context


Human

Location:	4q13.3
Sequence:	4; NC_000004.12 (70655541..70666508, complement)

Subcellular Localizations

Secreted.

Diseases

Leukemia
Stasis
Yin Deficiency
Hepatitis, Chronic
Extravasation
Melanoma
Hepatitis B
Aqueous Humor Disorders
Cytogenetic Abnormality
L1 Acute Lymphoblastic Leukemia
Turner Syndrome
Infective Disorder

Impacted Tooth
Fetal Diseases
Hepatitis
Acute Lymphocytic Leukemia
Hepatitis B, Chronic
Sex Chromosome Aberrations

Pathways

Transepithelial Transport
Transport
Disease Resistance
Reverse Transcription
Cell Development
Immune Response
Complement Activation

Secretion

PTMs

Disulfide bond

Glycoprotein

Pyrrolidone carboxylic acid

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/JCHAIN

References

PMID: 407930 by Mole J.E., et al. Primary structure of human J chain: alignment of peptides from chemical and enzymatic hydrolyses.

PMID: 2984306 by Max E.E., et al. Human J chain gene. Structure and expression in B lymphoid cells.