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- Table of Contents
KAT7 Antibodies
AND KAT7 ELISA kits, KAT7 Proteins
Many biological assays use antibodies to detect KAT7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KAT7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KAT7 antibodies...
Designing an IHC experiment for KAT7? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the KAT7 IHC GuideKAT7 Infographic by Boster Bio
All KAT7 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IP, IF, IHC, ICC, WB
$370
Cat # M03896
100 μl
Cat # M03896
100 μl
Human, Mouse, Rat
IP, IHC, WB
$405
Cat # A03896-1
100ul
Cat # A03896-1
100ul
KAT7 Overview
Facts about Histone acetyltransferase KAT7.
Histone acetyltransferase KAT7 (KAT7)
Part of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the majority of histone H4 acetylation in vivo. Involved in H3K14 (histone H3 lysine 14) acetylation and cell proliferation (By similarity).
During chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Acts as a coactivator of the licensing variable CDT1 (PubMed:18832067).
Gene Information
| Human | |
|---|---|
| Gene Name: | KAT7 |
| Uniprot: | O95251 |
| Entrez: | 11143 |
Family
| Belongs to: |
|---|
| MYST (SAS/MOZ) family |
Alternative Names
HBO1EC 2.3.1.48; HBOA; Histone acetyltransferase binding to ORC1; histone acetyltransferase MYST2; KAT7; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2; MYST histone acetyltransferase 2; MYST-2
Molecular Weight
Mass (kDA):
70.642 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q21.33 |
| Sequence: | 17; NC_000017.11 (49788681..49835026) |
Tissue Specificity
Ubiquitously expressed, with highest levels in testis.
Subcellular Localizations
Nucleus, nucleoplasm. Cytoplasm, cytosol. Nucleus. Associates with replication origins specifically during the G1 phase of the cell cycle (PubMed:18832067).
Diseases
- Neoplasms
- Malignant Neoplasms
- Multiple Organ Failure
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Leukemia
- Prostatic Neoplasms
- Hiv Infections
- Melanoma
- Tumor Progression
- Colonic Neoplasms
- Malignant Tumor Of Colon
Interacting Proteins
- AR
- BARD1
- CEP126
- PLK1
- VIM
Pathways
- Dna Replication
- Histone Acetylation
- Cell Cycle
- Cell Proliferation
- Histone H4 Acetylation
- Chromatin Remodeling
- Regulation Of Gene Expression
- Dosage Compensation
- Methylation
- Cell Death
- Gene Silencing
- Dna Hypermethylation
- Brain Development
PTMs
- Acetylation
- Methylation
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KAT7
bosterbio.com/bosterbio-gene-info-cards/KAT7
References
PMID: 10438470 by Iizuka M., et al. Histone acetyltransferase HBO1 interacts with the ORC1 subunit of the human initiator protein.
PMID: 10930412 by Sharma M., et al. Androgen receptor interacts with a novel MYST protein, HBO1.