KBTBD8 Antibodies

AND KBTBD8 ELISA kits, KBTBD8 Proteins

Many biological assays use antibodies to detect KBTBD8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KBTBD8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KBTBD8 antibodies...

We validate the specificity of these antibodies to KBTBD8 by testing them on tissues known to express KBTBD8 positively and negatively. Browse below to find the KBTBD8 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KBTBD8 Infographic by Boster Bio

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KBTBD8 (NM_032505) Human Recombinant Protein

Coomassie blue staining of purified KBTBD8 protein

$1249
Cat # PROTQ8NFY9
20 µg

KBTBD8 Overview

Facts about Kelch repeat and BTB domain-containing protein 8.

KBTBD8 3D structure. Source: alphafold

Kelch repeat and BTB domain-containing protein 8 (KBTBD8)

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (PubMed:26399832). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the creation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832).

Gene Information

Human
Gene Name:	KBTBD8
Uniprot:	Q8NFY9
Entrez:	84541

Family

Belongs to:

KBTBD8 family

Alternative Names

kelch repeat and BTB (POZ) domain containing 8; KIAA1842; TAKRP; T-cell activation kelch repeat protein

Molecular Weight

Mass (kDA):
68.823 kDA

Genomic Context


Human

Location:	3p14.1
Sequence:	3; NC_000003.12 (66998307..67011210)

Subcellular Localizations

Cytoplasm, cytoskeleton, spindle. Golgi apparatus. Translocates to the spindle apparatus during mitosis.

Diseases

Dwarfism
Growth Disorders

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KBTBD8

References

PMID: 23578279 by Luhrig S., et al. The novel BTB-kelch protein, KBTBD8, is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis.

PMID: 26399832 by Werner A., et al. Cell-fate determination by ubiquitin-dependent regulation of translation.