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KCND3 Antibodies
AND KCND3 ELISA kits, KCND3 Proteins
Many biological assays use antibodies to detect KCND3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KCND3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KCND3 antibodies...
Designing a Western blot for KCND3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the KCND3 Western Blot GuideKCND3 Infographic by Boster Bio
All KCND3 Products
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KCND3 Overview
Facts about Potassium voltage-gated channel subfamily D member 3.
Potassium voltage-gated channel subfamily D member 3 (KCND3)
Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons.
Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. .
Gene Information
| Human | |
|---|---|
| Gene Name: | KCND3 |
| Uniprot: | Q9UK17 |
| Entrez: | 3752 |
Family
| Belongs to: |
|---|
| potassium channel family |
Alternative Names
KCND3L; KCND3S; KSHIVB; Kv4.3; MGC142035; MGC142037; potassium ionic channel Kv4.3; potassium voltage-gated channel subfamily D member 3; potassium voltage-gated channel, Shal-related subfamily, member 3; sha1-related potassium channel Kv4.3; voltage-gated K+ channel; voltage-gated potassium channel Kv4.3; Voltage-gated potassium channel subunit Kv4.3
Molecular Weight
Mass (kDA):
73.451 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p13.2 |
| Sequence: | 1; NC_000001.11 (111770662..111989577, complement) |
Tissue Specificity
Highly expressed in heart and brain, in particular in cortex, cerebellum, amygdala and caudate nucleus. Detected at lower levels in liver, skeletal muscle, kidney and pancreas. Isoform 1 predominates in most tissues. Isoform 1 and isoform 2 are detected at similar levels in brain, skeletal muscle and pancreas.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Cell membrane, sarcolemma; Multi-pass membrane protein. Cell projection, dendrite. Interaction with palmitoylated KCNIP2 and KCNIP3 enhances cell surface expression.
Diseases
- Cardiac Arrhythmia
- Brugada Syndrome (disorder)
- Hypertrophy
- Long Qt Syndrome
- Heart Failure
- Cardiac Fibrillation
- Cardiac Hypertrophy
- Sudden Cardiac Death
- Infarction
- Myocardial Infarction
- Atrial Fibrillation
- Tachycardia, Ventricular
- Ataxia
Interacting Proteins
- KCNIP1
Pathways
- Localization
- Pathogenesis
- Transport
- Mrna Splicing
- Gene Silencing
- Parturition
- Protein Maturation
- Cell Growth
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KCND3
bosterbio.com/bosterbio-gene-info-cards/KCND3
References
PMID: 9843794 by Kong W., et al. Isolation and characterization of the human gene encoding Ito: further diversity by alternative mRNA splicing.
PMID: 10200233 by Dilks D., et al. Cloning and expression of the human Kv4.3 potassium channel.