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- Table of Contents
KCNH2 Antibodies
AND KCNH2 ELISA kits, KCNH2 Proteins
Many biological assays use antibodies to detect KCNH2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KCNH2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KCNH2 antibodies...
Designing a Western blot for KCNH2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the KCNH2 Western Blot GuideKCNH2 Infographic by Boster Bio
All KCNH2 Products
Product
Figures
Specificity
Applications
Price
Anti-MADH7/SMAD7 Antibody Picoband®
3 Citations
Human, Mouse, Rat
ELISA, WB
$370
Cat # A00784-2
100 μg/vial
Cat # A00784-2
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A00781-3
100 μg/vial
Cat # A00781-3
100 μg/vial
KCNH2 Overview
Facts about Potassium voltage-gated channel subfamily H member 2.
Potassium voltage-gated channel subfamily H member 2 (KCNH2)
Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly.
Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (PubMed:18559421, PubMed:26363003, PubMed:27916661). .
Gene Information
| Human | |
|---|---|
| Gene Name: | KCNH2 |
| Uniprot: | Q12809 |
| Entrez: | 3757 |
Family
| Belongs to: |
|---|
| potassium channel family |
Alternative Names
Eag homolog; Eag-related protein 1; ERG; erg1; ERG-1; Ether-a-go-go-related gene potassium channel 1; ether-a-go-go-related potassium channel protein; Ether-a-go-go-related protein 1; H-ERG; HERG1; HERGhERG-1; Kv11.1; LQT2; potassium voltage-gated channel subfamily H member 2; potassium voltage-gated channel, subfamily H (eag-related), member 2; SQT1; Voltage-gated potassium channel subunit Kv11.1
Molecular Weight
Mass (kDA):
126.655 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q36.1 |
| Sequence: | 7; NC_000007.14 (150944956..150978321, complement) |
Tissue Specificity
Highly expressed in heart and brain. Isoforms USO are frequently overexpressed in cancer cells.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein.
Diseases
- Long Qt Syndrome
- Cardiac Arrhythmia
- Sudden Cardiac Death
- Sudden Death
- Syncope
- Cardiac Death
- Long Qt Syndrome Congenital
- Torsades De Pointes
- Cardiac Fibrillation
- Tachycardia, Ventricular
- Heart Diseases
- Ventricular Fibrillation
Interacting Proteins
- CAV1
Pathways
- Pathogenesis
- Transport
- Glycosylation
- Localization
- Cell Cycle
- Cell Proliferation
- Cell Migration
- Swimming
- Translation
- Secretory Pathway
- Intracellular Transport
- Protein Folding
- Heart Development
PTMs
- Glycosylation
- Phosphorylation
Research Areas
- Neuroscience
- Neurotransmission
- Potassium Channels
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KCNH2
bosterbio.com/bosterbio-gene-info-cards/KCNH2
References
PMID: 8159766 by Warmke J.W., et al. A family of potassium channel genes related to eag in Drosophila and mammals.
PMID: 9600240 by Itoh T., et al. Genomic organization and mutational analysis of HERG, a gene responsible for familial long QT syndrome.
2 Publications of Boster KCNH2 Antibodies & ELISA Kits
- PubMed ID: 10.1371/journal.pone.0153409, Hydroxysafflor Yellow A Ameliorates Renal Fibrosis by Suppressing TGF-β1-Induce...
- PubMed ID: 10.1016/j.jep.2019.112404, Astragaloside IV inhibits cardiac fibrosis via miR-135a-TRPM7-TGF-β/Smads pathw...
*More publications can be found for each product on its corresponding product page