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- Table of Contents
Facts about Lysine-specific demethylase 2A.
May also recognize and bind to some phosphorylated proteins and encourage their ubiquitination and degradation. Required to keep the heterochromatic state.
| Human | |
|---|---|
| Gene Name: | KDM2A |
| Uniprot: | Q9Y2K7 |
| Entrez: | 22992 |

| Belongs to: |
|---|
| JHDM1 histone demethylase family |

[Histone-H3]-lysine-36 demethylase 1A; CXXC8F-box protein FBL7; CXXC-type zinc finger protein 8; FBL11DKFZp434M1735; FBL7F-box protein Lilina; F-box and leucine-rich repeat protein 11DKFZP434M1735; F-box protein FBL11; FBXL11FLJ46431; FLJ00115; JHDM1AF-box/LRR-repeat protein 11; JmjC domain-containing histone demethylation protein 1A; jumonji C domain-containing histone demethylase 1A; KIAA1004EC 1.14.11.27; LILINA; lysine (K)-specific demethylase 2A; lysine-specific demethylase 2A; SF-KDM2A
Mass (kDA):
132.793 kDA

| Human | |
|---|---|
| Location: | 11q13.2 |
| Sequence: | 11; NC_000011.10 (67119263..67258082) |
Widely expressed, with highest levels in brain, testis and ovary, followed by lung.
Nucleus, nucleoplasm. Punctate expression throughout the nucleoplasm and enriched in the perinucleolar region. Specifically nucleates at CpG islands where it's presence results in chromatin depleted in H3K36me2.





PMID: 10945468 by Ilyin G.P., et al. cDNA cloning and expression analysis of new members of the mammalian F-box protein family.
PMID: 11214971 by Hattori A., et al. Characterization of long cDNA clones from human adult spleen.