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- Table of Contents
KDM6B Antibodies
AND KDM6B ELISA kits, KDM6B Proteins
Many biological assays use antibodies to detect KDM6B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KDM6B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KDM6B antibodies...
Designing a Western blot for KDM6B? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the KDM6B Western Blot GuideKDM6B Infographic by Boster Bio
All KDM6B Products
Product
Figures
Specificity
Applications
Price
Anti-KDM6B/JMJD3 Picoband® Antibody
1 Citations
Human, Mouse
ELISA, Flow Cytometry, WB
$370
Cat # A01309-1
100 μg/vial
Cat # A01309-1
100 μg/vial
KDM6B Overview
Facts about Lysine-specific demethylase 6B.
Lysine-specific demethylase 6B (KDM6B)
Histone demethylase that especially demethylates'Lys- 27' of histone H3, thereby playing a central role in histone code (PubMed:17825402, PubMed:17851529, PubMed:17713478, PubMed:18003914). Demethylates trimethylated and dimethylated H3 'Lys-27' (PubMed:17825402, PubMed:17851529, PubMed:17713478, PubMed:18003914).
Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Involved in inflammatory reaction by engaging in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation (PubMed:17825402).
Gene Information
| Human | |
|---|---|
| Gene Name: | KDM6B |
| Uniprot: | O15054 |
| Entrez: | 23135 |
Family
| Belongs to: |
|---|
| UTX family |
Alternative Names
EC 1.14.11; EC 1.14.11.-; JmjC domain-containing protein 3; JMJD3; JMJD3lysine-specific demethylase 6B; jumonji domain containing 3, histone lysine demethylase; Jumonji domain-containing protein 3; KDM6B; KIAA0346jumonji domain containing 3; Lysine (K)specific Demethylase 6B; Lysine (K)-specific Demethylase 6B; Lysine demethylase 6B
Molecular Weight
Mass (kDA):
176.632 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17p13.1 |
| Sequence: | 17; NC_000017.11 (7834210..7854796) |
Subcellular Localizations
Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Inflammation
- Retinoblastoma
- Leukemia
- Lymphoma
- Prostatic Neoplasms
- Teratoma
- Infective Disorder
- Malignant Neoplasm Of Prostate
- Neoplasm Metastasis
- Malignant Neoplasm Of Breast
- Carcinoma
Interacting Proteins
- ESR1
Pathways
- Methylation
- Demethylation
- Gene Silencing
- Neurogenesis
- Senescence
- Cell Differentiation
- Histone Methylation
- Histone Modification
- Cellular Senescence
- Histone Acetylation
- Pathogenesis
- Cell Death
- Neural Tube Closure
PTMs
- Methylation
- Demethylation
- Reduction
Research Areas
- Cancer
- Chromatin Research
- Transcription Factors and Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KDM6B
bosterbio.com/bosterbio-gene-info-cards/KDM6B
References
PMID: 17193924 by Hu L.Y., et al. An efficient strategy to identify early TPA-responsive genes during differentiation of HL-60 cells.
PMID: 17825402 by De Santa F., et al. The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing.