Kallikrein-7 Antibodies

AND KLK7 ELISA kits, Kallikrein-7 Proteins

Many biological assays use antibodies to detect Kallikrein-7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Kallikrein-7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Kallikrein-7 antibodies...

We validate the specificity of these antibodies to Kallikrein-7 by testing them on tissues known to express KLK7 positively and negatively. Browse below to find the KLK7 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KLK7 Infographic by Boster Bio

All KLK7 Products

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Product

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Specificity

Applications

Price

Anti-Kallikrein-7 KLK7 Antibody

Human, Mouse, Rat

$405
Cat # A02739
100ul

Kallikrein 7 (KLK7) (NM_005046) Human Recombinant Protein

$813
Cat # PROTP49862
20 µg

Kallikrein 7 (KLK7) (NM_005046) Human Over-expression Lysate

Human

$628
Cat # LS005650
100 µg

Anti-Klk7 Antibody Picoband®

Rat

ELISA, IHC, WB

$370
Cat # A02739-1
100 µg/vial

KLK7 Overview

Facts about Kallikrein-7.

KLK7 3D structure. Source: alphafold

Kallikrein-7 (KLK7)

May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin at the constant shedding of cells from the skin surface. Particular for amino acid residues with aromatic side chains at the P1 position.

Cleaves insulin A chain at '14-Tyr-.

Gene Information

Human
Gene Name:	KLK7
Uniprot:	P49862
Entrez:	5650

Family

Belongs to:

peptidase S1 family

Alternative Names

EC 3.4.21; EC 3.4.21.117; hK7; hSCCE; kallikrein 7 (chymotryptic, stratum corneum); Kallikrein 7; kallikrein-related peptidase 7; KLK7; protease, serine, 6; PRSS6; SCCEkallikrein-7; Serine protease 6; signal protein; Stratum corneum chymotryptic enzyme

Molecular Weight

Mass (kDA):
27.525 kDA

Genomic Context


Human

Location:	19q13.41
Sequence:	19; NC_000019.10 (50976468..50984064, complement)

Tissue Specificity

Abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Also expressed in the brain, mammary gland, cerebellum, spinal cord and kidney. Lower levels in salivary glands, uterus, thymus, thyroid, placenta, trachea and testis. Up-regulated in ovarian carcinoma, especially late-stage serous carcinoma, compared with normal ovaries and benign adenomas (at protein level).

Subcellular Localizations

Secreted. In ovarian carcinoma, secreted and also observed at the apical membrane and in cytoplasm at the invasive front.

Diseases

Malignant Neoplasms
Neoplasms
Dermatitis
Dermatitis, Atopic
Carcinoma
Dermatologic Disorders
Malignant Neoplasm Of Ovary
Ovarian Neoplasm
Adenocarcinoma
Malignant Paraganglionic Neoplasm
Ichthyosis Linearis Circumflexa
Cell Invasion
Neoplasm Metastasis

Malignant Neoplasm Of Breast
Psoriasis
Inflammation
Tissue Adhesions
Carcinogenesis
Malignant Squamous Cell Neoplasm
Hyperkeratosis

Pathways

Localization
Pathogenesis
Proteolysis
Cell Adhesion
Secretion
Keratinization
Keratinocyte Differentiation
Cornification
Inflammatory Response
Keratinocyte Proliferation
Transport
Cell Proliferation
Sensory Processing

Gene Silencing
Glycosylation
Pigmentation
Skin Development
Endocytosis
Reverse Transcription
Delamination

PTMs

Cleavage

Glycosylation

Deglycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KLK7

References

PMID: 8034709 by Hansson L., et al. Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase.

PMID: 10974542 by Yousef G.M., et al. The KLK7 (PRSS6) gene, encoding for the stratum corneum chymotryptic enzyme is a new member of the human kallikrein gene family -- genomic characterization, mapping, tissue expression and hormonal regulation.