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- Table of Contents
Facts about Ragulator complex protein LAMTOR2.
Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
Human | |
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Gene Name: | LAMTOR2 |
Uniprot: | Q9Y2Q5 |
Entrez: | 28956 |
Belongs to: |
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GAMAD family |
ENDAP; Endosomal adaptor protein p14; HSPC003; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2; late endosomal/lysosomal adaptor, MAPK and MTOR activator 2; Late endosomal/lysosomal Mp1-interacting protein; MAPBPIPRoadblock domain-containing protein 3; MAPKSP1 adaptor protein; MAPKSP1AP; mitogen-activated protein-binding protein-interacting protein (MAPBPIP); Mitogen-activated protein-binding protein-interacting protein; p14Ragulator2; roadblock domain containing 3; ROBLD3
Mass (kDA):
13.508 kDA
Human | |
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Location: | 1q22 |
Sequence: | 1; NC_000001.11 (156054782..156058506) |
Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side.
PMID: 17897319 by Schroeder B., et al. Integral and associated lysosomal membrane proteins.
PMID: 17195838 by Bohn G., et al. A novel human primary immunodeficiency syndrome caused by deficiency of the endosomal adaptor protein p14.