This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
La-related protein 1 Antibodies
AND LARP1 ELISA kits, La-related protein 1 Proteins
Many biological assays use antibodies to detect La-related protein 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with La-related protein 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop La-related protein 1 antibodies...
Designing a Western blot for La-related protein 1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the LARP1 Western Blot GuideLARP1 Infographic by Boster Bio
All LARP1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A04488-2
100 μg/vial
Cat # A04488-2
100 μg/vial
LARP1 Overview
Facts about La-related protein 1.
La-related protein 1 (LARP1)
RNA-binding protein that promotes translation of certain classes of mRNAs downstream of the mTORC1 complex (PubMed:24532714, PubMed:25940091). Associates with the mRNA 5'cap in an MTOR-dependent manner and associates with mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding for ribosomal proteins and lots of components of the translation machinery (PubMed:24532714, PubMed:25940091, PubMed:26206669).
Associates with actively translating ribosomes via interaction with PABPC1/PABP and stimulates translation of mRNAs containing a 5'TOP, thereby regulating cell growth and proliferation (PubMed:20430826, PubMed:25940091). Positively regulates the replication of dengue virus (DENV) (PubMed:26735137).
Gene Information
| Human | |
|---|---|
| Gene Name: | LARP1 |
| Uniprot: | Q6PKG0 |
| Entrez: | 23367 |
Family
| Belongs to: |
|---|
| LARP family |
Alternative Names
KIAA0731LARPMGC19556; La ribonucleoprotein domain family member 1; La ribonucleoprotein domain family, member 1; la-related protein 1
Molecular Weight
Mass (kDA):
123.51 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q33.2 |
| Sequence: | 5; NC_000005.10 (154682979..154817605) |
Subcellular Localizations
Cytoplasm. Cytoplasmic granule. Colocalizes with RPTOR and PABPC1 in cytoplasmic granules that resemble stress granules.
Diseases
- Malignant Neoplasms
- Neoplasms
- Mammary Neoplasms
- Lung Neoplasms
- Prostatic Neoplasms
- Malignant Neoplasm Of Breast
Interacting Proteins
- CCDC155
Pathways
- Translation
- Transport
- Cell Division
- Vesicle Transport
- Cell Migration
- Cell Proliferation
- Head Involution
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LARP1
bosterbio.com/bosterbio-gene-info-cards/LARP1
References
PMID: 17693683 by Tang L.-Y., et al. Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction.
PMID: 20430826 by Burrows C., et al. The RNA binding protein Larp1 regulates cell division, apoptosis and cell migration.