LARS1 Antibodies

AND LARS1 ELISA kits, LARS1 Proteins

Many biological assays use antibodies to detect LARS1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LARS1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LARS1 antibodies...

We validate the specificity of these antibodies to LARS1 by testing them on tissues known to express LARS1 positively and negatively. Browse below to find the LARS1 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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LARS1 Infographic by Boster Bio

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LARS1 Overview

Facts about Leucine--tRNA ligase, cytoplasmic.

LARS1 3D structure. Source: alphafold

Leucine--tRNA ligase, cytoplasmic (LARS1)

Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is initially triggered by ATP to form AA-AMP and then moved to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs.

Gene Information

Human
Gene Name:	LARS1
Uniprot:	Q9P2J5
Entrez:	51520

Family

Belongs to:

class-I aminoacyl-tRNA synthetase family

Alternative Names

Leucine--tRNA ligase, cytoplasmic

Molecular Weight

Mass (kDA):
134.466 kDA

Genomic Context


Human

Location:	5q32
Sequence:	5; NC_000005.10 (146113026..146182787, complement)

Subcellular Localizations

Cytoplasm.

Diseases

Infantile liver failure syndrome 1 (ILFS1)

Interacting Proteins

RARS
RPTOR
RRAGD

PTMs

Acetylation

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LARS1

References

PMID: 19426743 by Seiradake E., et al. Crystal structures of the human and fungal cytosolic Leucyl-tRNA synthetase editing domains: A structural basis for the rational design of antifungal benzoxaboroles.

PMID: 22607940 by Casey J.P., et al. Identification of a mutation in LARS as a novel cause of infantile hepatopathy.