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- Table of Contents
Facts about Leptin receptor gene-related protein.
May play a role in liver resistance to GH during periods of reduced nutrient availability. .
Human | |
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Gene Name: | LEPROT |
Uniprot: | O15243 |
Entrez: | 54741 |
Belongs to: |
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OB-RGRP/VPS55 family |
DnaJ (Hsp40) homolog, subfamily C, member 6; Endospanin-1; LEPR; Leptin Receptor Gene Related Protein; Leptin Receptor Gene-Related Protein; Leptin Receptor Overlapping Transcript Protein; Leptin Receptor Overlapping Transcript; OB-R Gene-Related Protein; OBR; OBRGRP; Vps55
Mass (kDA):
14.254 kDA
Human | |
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Location: | 1p31.3 |
Sequence: | 1; NC_000001.11 (65420668..65436007) |
Expressed at the highest levels in heart and placenta and at a lesser extent in lung, liver, skeletal muscle, kidney and pancreas.
Golgi apparatus membrane; Multi-pass membrane protein. Endosome membrane.
PMID: 9207021 by Bailleul B., et al. The leptin receptor promoter controls expression of a second distinct protein.
PMID: 18042720 by Couturier C., et al. Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity.