LEPROT Antibodies

AND LEPROT ELISA kits, LEPROT Proteins

Many biological assays use antibodies to detect LEPROT, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LEPROT in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LEPROT antibodies...

We validate the specificity of these antibodies to LEPROT by testing them on tissues known to express LEPROT positively and negatively. Browse below to find the LEPROT antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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LEPROT Infographic by Boster Bio

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LEPROT (NM_017526) Human Over-expression Lysate

Human

$628
Cat # LS054741
20 µg, 100 µg

LEPROT Overview

Facts about Leptin receptor gene-related protein.

LEPROT 3D structure. Source: alphafold

Leptin receptor gene-related protein (LEPROT)

Negatively regulates leptin receptor (LEPR) cell surface expression, and consequently decreases response to leptin. Negatively regulates growth hormone (GH) receptor cell surface expression .

May play a role in liver resistance to GH during periods of reduced nutrient availability. .

Gene Information

Human
Gene Name:	LEPROT
Uniprot:	O15243
Entrez:	54741

Family

Belongs to:

OB-RGRP/VPS55 family

Alternative Names

DnaJ (Hsp40) homolog, subfamily C, member 6; Endospanin-1; LEPR; Leptin Receptor Gene Related Protein; Leptin Receptor Gene-Related Protein; Leptin Receptor Overlapping Transcript Protein; Leptin Receptor Overlapping Transcript; OB-R Gene-Related Protein; OBR; OBRGRP; Vps55

Molecular Weight

Mass (kDA):
14.254 kDA

Genomic Context


Human

Location:	1p31.3
Sequence:	1; NC_000001.11 (65420668..65436007)

Tissue Specificity

Expressed at the highest levels in heart and placenta and at a lesser extent in lung, liver, skeletal muscle, kidney and pancreas.

Subcellular Localizations

Golgi apparatus membrane; Multi-pass membrane protein. Endosome membrane.

Diseases

Diabetes Mellitus, Non-insulin-dependent
Obesity
Diabetes Mellitus
Insulin Resistance
Growth Retardation
Diabetes Mellitus, Experimental

Pituitary Diseases

Interacting Proteins

LEPR
TMEM50A

Pathways

Glucose Homeostasis
Translation
Gene Silencing
Mrna Processing

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LEPROT

References

PMID: 9207021 by Bailleul B., et al. The leptin receptor promoter controls expression of a second distinct protein.

PMID: 18042720 by Couturier C., et al. Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity.