LIMS2 Antibodies

AND LIMS2 ELISA kits, LIMS2 Proteins

Many biological assays use antibodies to detect LIMS2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LIMS2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LIMS2 antibodies...

We validate the specificity of these antibodies to LIMS2 by testing them on tissues known to express LIMS2 positively and negatively. Browse below to find the LIMS2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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LIMS2 Infographic by Boster Bio

All LIMS2 Products

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Anti-LIMS2 Mouse Monoclonal Antibody [Clone ID: OTI5H8]

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LIMS2 (Right lane) cDNA for 48 hrs and lysed

Western blot analysis of extracts (35ug) from mouse liver tissue lysate by using anti-LIMS2 monoclonal antibody (1:500)

Human, Mouse, Rat

$523
Cat # M08256
100 µl

Anti-LIMS2 Antibody

Human, Mouse, Rat

ELISA, WB

$370
Cat # A08256-3
100 μl/vial

LIMS2 Overview

Facts about LIM and senescent cell antigen-like-containing domain protein 2.

LIMS2 3D structure. Source: alphafold

LIM and senescent cell antigen-like-containing domain protein 2 (LIMS2)

Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complicated to cell surface receptor tyrosine kinases and growth factor receptors. Plays a role in regulating cell migration and spreading.

Gene Information

Human
Gene Name:	LIMS2
Uniprot:	Q7Z4I7
Entrez:	55679

Family

Belongs to:

No superfamily

Alternative Names

FLJ10044; ILK-binding protein; LIM and senescent cell antigen-like domains 2; LIM and senescent cell antigen-like-containing domain protein 2; LIM-like protein 2; Particularly interesting new Cys-His protein 2; PINCH2; PINCH-2

Molecular Weight

Mass (kDA):
38.916 kDA

Genomic Context


Human

Location:	2q14.3
Sequence:	2; NC_000002.12 (127638381..127681786, complement)

Subcellular Localizations

Nucleus. Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Diseases

Tissue Adhesions
Malignant Neoplasms
Neoplasm Metastasis
Stomach Neoplasms
Infarction
Tumor Progression
Endometrial Polyp
Carcinogenesis
Carcinoma
Fibrosis
Myocardial Infarction
Neoplasms

Mammary Neoplasms
Epithelial Ovarian Cancer
Ovarian Neoplasm
Mesothelioma
Cell Invasion
Adenocarcinoma
Malignant Mesothelioma

Interacting Proteins

CALCOCO2
GOLGA2
KRT40
KRTAP10-5
KRTAP10-7

MDFI
MTUS2
NOTCH2NL
RCHY1

Pathways

Cell Adhesion
Localization
Cell Growth
Cell Proliferation
Cell Migration
Regulation Of Gene Expression
Insemination
Methylation
Posttranscriptional Regulation Of Gene Expression

Cell Motility
Stem Cell Proliferation
Estrus
Cell-cell Adhesion

PTMs

Phosphorylation

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LIMS2

References

PMID: 12167643 by Zhang Y., et al. Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migration.

PMID: 19963065 by Chiswell B.P., et al. Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase.