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- Table of Contents
Protein lin-28 homolog B Antibodies
AND Lin28b ELISA kits, Protein lin-28 homolog B Proteins
Many biological assays use antibodies to detect Protein lin-28 homolog B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein lin-28 homolog B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein lin-28 homolog B antibodies...
Designing a Western blot for Protein lin-28 homolog B? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the LIN28B Western Blot GuideLin28b Infographic by Boster Bio
All Lin28b Products
Product
Figures
Specificity
Applications
Price
Anti-Lin28B Rabbit Monoclonal Antibody
1 Citations
Human
Flow Cytometry, IP, IF, ICC, WB
$370
Cat # M00896
100 μl
Cat # M00896
100 μl
Lin28b Overview
Facts about Protein lin-28 homolog B.
Protein lin-28 homolog B (Lin28b)
Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and maybe of miR107, miR-143 and miR-200c. Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away in the microprocessor complex, hence preventing their processing into mature miRNA.
Does not act on pri-miR21. The repression of let-7 expression is required for normal development and contributes to keep the pluripotent state of embryonic stem cells by preventing let-7-mediated differentiation.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Lin28b |
| Uniprot: | Q45KJ6 |
| Entrez: | 380669 |
Family
| Belongs to: |
|---|
| lin-28 family |
Alternative Names
CSDD2; CSDD2protein lin-28 homolog B; FLJ16517; lin-28 homolog B (C. elegans); Lin-28.2; LIN28B; LIN-28B
Molecular Weight
Mass (kDA):
26.903 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 10|10 B2 |
| Sequence: | 10; |
Diseases
- Malignant Neoplasms
- Neoplasms
- Cell Transformation, Neoplastic
- Precocious Puberty
- Neoplasm Metastasis
- Carcinoma
- Ovarian Neoplasm
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Liver Carcinoma
- Diabetes Mellitus
- Malignant Neoplasm Of Ovary
Pathways
- Menarche
- Cell Proliferation
- Cell Cycle
- Cell Growth
- Pathogenesis
- Cell Migration
- Menopause
- Translation
- Oncogenesis
- Gastrulation
- Cell Aging
- Cell Development
- Aging
PTMs
- Cleavage
Research Areas
- Epigenetics
- Neuroscience
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Lin28b
bosterbio.com/bosterbio-gene-info-cards/Lin28b
References
PMID: 19211792 by Chang T.-C., et al. Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation.