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Facts about Lamin-B2.
Mouse | |
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Gene Name: | Lmnb2 |
Uniprot: | P21619 |
Entrez: | 16907 |
Belongs to: |
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intermediate filament family |
lamin B2; lamin-B2; LMN2LAMB2; MGC2721
Mass (kDA):
67.318 kDA
Mouse | |
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Location: | 10 C1|10 39.72 cM |
Sequence: | 10; |
Isoform B3 is germ cell specific.
Are you curious about Boster Bio Anti-Lamin B2/LMNB2 markers? This article will cover its validation, applications, and references. Then, you can decide whether this antibody is right for your research. This article also provides information about the protein. This is an important part in the Boster Bio overview, as it explains what this marker does.
Boster Bio Anti-Lamin B2/LMB2Marker is an antibody that reacts against Human, Mouse and Rat. This antibody recognizes lamin B2 protein's 620 amino acids. Boster Bio is among the many suppliers of anti-lamin-B2 antibodies. It is available for animal and human use. Many have been proven to be effective.
This antibody allows researchers to detect the presence this protein in tissue samples or cells. Boster validates antibodies with positive and negatively sampled samples to ensure specificity. It also rewards scientists who review its products. You can get product credits to recognize scientists from around the world. The Food and Drug Administration has not approved this antibody. Visit the Boster Bio website for more information.
The Abcam antibody detects lamin B2's epitope, which is not universally available. This antibody is not compatible with other cell types, including human. However, the company is actively working to address this reproducibility crisis by using knockout edited cells lines and gold-standard validation. This is a great company to choose if you want a high-quality antigen.
This genetic marker can be used in a variety of cancers. It plays a critical role in the apoptosis pathway, and has been associated to poor prognosis. It has been proven that LMNB2 expression in a number sarcomas is significantly higher. This marker has also been linked to the number and stage of tumor nodules.
Inactivating or modifying LMNB2 gene expression in mouse models altered the ploidy and progression of metaphase in mice. It also promoted polyploid cardiomyocytes nuclei and reduced myocardial regeneration. These findings suggest that modifying LMNB2 expression can lead to improved outcomes in cardiomyocyte regeneration and M-phase progression. Ultimately, the research behind the LMNB2 marker has the potential to improve the care of cardiomyocytes.
The LMNB1 genes are a member of lamin families. It is involved with cytoskeleton interaction, protein interaction and chromatin regulation as well as DNA damage repairs. Its role in cancer biomarker and research is undeniable, even though the exact impact of LMNB1 upon tumor cell growth remains unclear. It also plays an important role in the reassembly or reorganization of the nuclear shell after cell division.
Although LMNB2 is a candidate for a number cancers, it is not clear what disease it causes. The LMNB2 gene is also frequently mutated in melanoma. This gene can be used as an indicator gene for cancer research. It may help uncover new disease-causing mutations. Although still in its infancy, LMNB2 is already helping researchers to develop better treatments for this disease.
Multiple methods were used to validate the LMNB2 marker. The LMNB2 markers were used in this study for identifying cells expressing LMNA/GFAP1. The IPA method was used to identify the proteins that corresponded to the human LMNB2 mark and uPAR. Six validated proteins were also identified that were linked to the av or uPAR.
The LMNB2 gene encodes a type V intermediate filament that is embedded in the inner nuclear membrane. Global nuclear organization is determined by lamins which are major architectural proteins in the nucleus. They also regulate movement and anchor chromatin domains. Many human diseases are caused by defects in nuclear-envelope-specific proteins, such as LMNB2 & LMNA. They are also implicated in cytoplasmic structure and cytoskeletal mechanics.
The LMNB2 protein encodes a protein that can be found in most cells. It is a member of the lamin superfamily. This protein has multiple roles in normal tissue formation and disease. In PCa cells, LMNB2 overexpression stimulates colony formation, migration and invasion. Moreover, LMNB2 is overexpressed in cancer tissues. This gene is associated both with invasiveness as well as EMT via indirect downregulation E-cadherin.
PMID: 2102682 by Hoeger T.H., et al. Characterization of a second highly conserved B-type lamin present in cells previously thought to contain only a single B-type lamin.
PMID: 8094052 by Furukawa K., et al. cDNA cloning of a germ cell specific lamin B3 from mouse spermatocytes and analysis of its function by ectopic expression in somatic cells.
*More publications can be found for each product on its corresponding product page