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- Table of Contents
Lpin1 Antibodies
AND Lpin1 ELISA kits, Lpin1 Proteins
Many biological assays use antibodies to detect Lpin1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Lpin1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Lpin1 antibodies...
Designing an IHC experiment for Lpin1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the LPIN1 IHC GuideLpin1 Infographic by Boster Bio
All Lpin1 Products
Product
Figures
Specificity
Applications
Price
Human, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A02467-2
100 µg/vial
Cat # A02467-2
100 µg/vial
Human, Mouse
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M02467-1
100 μl/vial
Cat # M02467-1
100 μl/vial
Lpin1 Overview
Facts about Phosphatidate phosphatase LPIN1.
Phosphatidate phosphatase LPIN1 (Lpin1)
Plays important roles in controlling the metabolism of fatty acids at different levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis.
Acts also as nuclear transcriptional coactivator for PPARGC1A/PPARA regulatory pathway to modulate lipid metabolism gene expression. Is involved in adipocyte differentiation.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Lpin1 |
| Uniprot: | Q91ZP3 |
| Entrez: | 14245 |
Family
| Belongs to: |
|---|
| lipin family |
Alternative Names
DKFZp781P1796; EC 3.1.3.18; EC 3.1.3.4; EC 5.4.2.7; KIAA0188phosphatidate phosphatase LPIN1; Lipin 1; lipin-1; LPIN1; PAP1
Molecular Weight
Mass (kDA):
102.002 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 12 A1.1|12 7.9 cM |
| Sequence: | 12; |
Tissue Specificity
Specifically expressed in skeletal muscle. Also expressed prominently in adipose tissue, and testis. Lower expression also detected in kidney, lung, brain and liver. Isoform 1 is the predominant isoform in the liver. Isoform 2 is the major form in the brain.
Diseases
- Obesity
- Insulin Resistance
- Lipodystrophy
- Fatty Liver
- Diabetes Mellitus
- Dystrophy
- Insulin Sensitivity
- Diabetes Mellitus, Non-insulin-dependent
- Steatosis
- Inflammation
- Steatohepatitis
- Nervousness
Pathways
- Localization
- Fatty Acid Oxidation
- Secretion
- Tissue Development
- Adipose Tissue Development
- Lipid Homeostasis
- Glucose Homeostasis
- Pathogenesis
- Lactation
- Transport
- Cell Differentiation
- Mrna Splicing
- Lipid Oxidation
PTMs
- Oxidation
- Phosphorylation
- Dephosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Lpin1
bosterbio.com/bosterbio-gene-info-cards/Lpin1
References
PMID: 11792863 by Huffman T.A., et al. Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin.
PMID: 11138012 by Peterfy M., et al. Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin.