E3 ubiquitin-protein ligase LRSAM1 (LRSAM1)

E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the capability of TSG101 to form endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos (PubMed:15256501). Bacterial recognition protein which defends the cytoplasm from invasive pathogens (PubMed:23245322).

Localizes to several intracellular bacterial pathogens and creates the bacteria- related ubiquitin signal resulting in autophagy-mediated intracellular bacteria degradation (xenophagy) (PubMed:23245322, PubMed:25484098). .